Ultraviolet radiation-induced DNA damage is prognostic for outcome in melanoma

Research output: Contribution to journalArticle

  • External authors:
  • Lucas D Trucco
  • Piyushkumar A Mundra
  • Kate Hogan
  • Pablo Garcia-Martinez
  • Amaya Viros
  • Amit K Mandal
  • Nicolas Macagno
  • Caroline Gaudy-Marqueste
  • Donald Allan
  • Franziska Baenke
  • Martin Cook
  • Clare McManus
  • Berta Sanchez-Laorden
  • Nathalie Dhomen

Abstract

The melanoma genome is dominated by ultraviolet radiation (UVR)-induced mutations. Their relevance in disease progression is unknown. Here we classify melanomas by mutation signatures and identify ten recurrently mutated UVR signature genes that predict patient survival. We validate these findings in primary human melanomas; in mice we show that this signature is imprinted by short-wavelength UVR and that four exposures to UVR are sufficient to accelerate melanomagenesis.

Bibliographical metadata

Original languageEnglish
JournalNature Medicine
Early online date3 Dec 2018
DOIs
Publication statusE-pub ahead of print - 3 Dec 2018