Tumour oxygenation levels correlate with dynamic contrast-enhanced magnetic resonance imaging parameters in carcinoma of the cervix

Research output: Contribution to journalArticle

  • External authors:
  • Rachel A. Cooper
  • Bernadette M. Carrington
  • Juliette A. Loncaster
  • Susan M. Todd
  • Susan E. Davidson
  • John P. Logue
  • Asha D. Luthra
  • Andrew P. Jones
  • Robert D. Hunter

Abstract

Background and purpose: The Eppendorf pO2 histograph is the 'gold standard' method for measuring tumour oxygenation. The method is not suitable for widespread application because its use is limited to accessible tumours. A non-invasive imaging technique would be an attractive alternative. Therefore, the relationships between tumour oxygenation and dynamic contrast-enhanced magnetic resonance imaging (MRI) parameters were investigated. Materials and methods: The study comprised 30 patients with carcinoma of the cervix. Tumour oxygenation was measured pre-treatment as median pO2 and the proportion of values less than 5 mmHg (HP5) using a pO2 histograph. Repeat measurements were obtained for nine patients following 40-45 Gy external beam radiotherapy giving a total of 39 measurements. Dynamic contrast-enhanced MRI using gadolinium was performed prior to obtaining the oxygenation data. Time/signal intensity curves were generated to obtain two standard parameters: maximum enhancement over baseline (SI-I) and the rate of enhancement (SI-I/s). Results: Using the 39 measurements, there was a significant correlation between SI-I and both median pO2 (r=0.59; P

Bibliographical metadata

Original languageEnglish
Pages (from-to)53-59
Number of pages6
JournalRadiotherapy and Oncology
Volume57
Issue number1
DOIs
Publication statusPublished - 1 Oct 2000