Treatment Outcome in Early Diffuse Cutaneous Systemic Sclerosis: The European Scleroderma Observational Study [ESOS]

Research output: Contribution to journalArticle

  • External authors:
  • Xiaoyan Pan
  • Sebastien Peytrignet
  • Roger Hesselstrand
  • Portugal Luc Mouthon
  • Alan Silman
  • Edith Brown
  • László Czirják
  • Jörg Hw Distler
  • Oliver Distler
  • Kim Fligelstone
  • William J Gregory
  • Rachel Ochiel
  • Madelon C Vonk
  • Codrina Ancuţa
  • Voon H Ong
  • Dominique Farge
  • Marie Hudson
  • Marco Matucci-Cerinic
  • Alexandra Balbir-Gurman
  • Øyvind Midtvedt
  • Alison C Jordan
  • Paresh Jobanputra
  • Wendy Stevens
  • Pia Moinzadeh
  • Frances C Hall
  • Christian Agard
  • Marina E Anderson
  • Elisabeth Diot
  • Rajan Madhok
  • Mohammed Akil
  • Maya H Buch
  • Lorinda Chung
  • Nemanja Damjanov
  • Harsha Gunawardena
  • Peter Lanyon
  • Yasmeen Ahmad
  • Kuntal Chakravarty
  • Soren Jacobsen
  • Alexander J MacGregor
  • Neil J. McHugh
  • Ulf Müller-Ladner
  • Gabriela Riemekasten
  • Michael Becker
  • Janet Roddy
  • Patricia E Carreira
  • Anne Laure Fauchais
  • Eric Hachulla
  • Jennifer Hamilton
  • Murat Inanç
  • John S McLaren
  • Jacob M. van Laar
  • Sanjay Pathare
  • Susannah Proudman
  • Anna Rudin
  • Joanne Sahhar
  • Brigitte Coppere
  • Christine Serratrice
  • Tom Sheeran
  • Douglas J Veale
  • Claire Grange
  • Georges-Selim Trad
  • Christopher P. Denton

Abstract

Objectives The rarity of early diffuse cutaneous systemic sclerosis (dcSSc) makes randomised controlled trials very difficult. We aimed to use an observational approach to compare effectiveness of currently used treatment approaches.

Methods This was a prospective, observational cohort study of early dcSSc (within three years of onset of skin thickening). Clinicians selected one of four protocols for each patient: methotrexate, mycophenolate mofetil (MMF), cyclophosphamide or ‘no immunosuppressant’. Patients were assessed three-monthly for up to 24 months. The primary outcome was the change in modified Rodnan skin score (mRSS). Confounding by indication at baseline was accounted for using inverse probability of treatment (IPT) weights. As a secondary outcome, an IPT-weighted Cox model was used to test for differences in survival.

Results Of 326 patients recruited from 50 centres, 65 were prescribed methotrexate, 118 MMF, 87 cyclophosphamide and 56 no immunosuppressant. 276 (84.7%) patients completed 12 and 234 (71.7%) 24 months follow-up (or reached last visit date). There were statistically significant reductions in mRSS at 12 months in all groups: −4.0 (−5.2 to −2.7) units for methotrexate, −4.1 (−5.3 to −2.9) for MMF, −3.3 (−4.9 to −1.7) for cyclophosphamide and −2.2 (−4.0 to −0.3) for no immunosuppressant (p value for between-group differences=0.346). There were no statistically significant differences in survival between protocols before (p=0.389) or after weighting (p=0.440), but survival was poorest in the no immunosuppressant group (84.0%) at 24 months.

Conclusions These findings may support using immunosuppressants for early dcSSc but suggest that overall benefit is modest over 12 months and that better treatments are needed.

Bibliographical metadata

Original languageEnglish
Pages (from-to)1207-1218
Number of pages12
JournalAnnals of the rheumatic diseases
Volume76
Early online date10 Feb 2017
DOIs
Publication statusPublished - 1 Jul 2017

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