Translational selection frequently overcomes genetic drift in shaping synonymous codon usage patterns in vertebrates.Citation formats

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Translational selection frequently overcomes genetic drift in shaping synonymous codon usage patterns in vertebrates. / Mcinerney, James; Doherty, Aoife; McInerney, James O.

In: Molecular Biology and Evolution, Vol. 30, No. 10, 10.2013.

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Mcinerney, James ; Doherty, Aoife ; McInerney, James O. / Translational selection frequently overcomes genetic drift in shaping synonymous codon usage patterns in vertebrates. In: Molecular Biology and Evolution. 2013 ; Vol. 30, No. 10.

Bibtex

@article{23f07fc629b44586818dc3ffe3e8e5db,
title = "Translational selection frequently overcomes genetic drift in shaping synonymous codon usage patterns in vertebrates.",
abstract = "Synonymous codon usage patterns are shaped by a balance between mutation, drift, and natural selection. To date, detection of translational selection in vertebrates has proven to be a challenging task, obscured by small long-term effective population sizes in larger animals and the existence of isochores in some species. The consensus is that, in such species, natural selection is either completely ineffective at overcoming mutational pressures and genetic drift or perhaps is effective but so weak that it is not detectable. The aim of this research is to understand the interplay between mutation, selection, and genetic drift in vertebrates. We observe that although variation in mutational bias is undoubtedly the dominant force influencing codon usage, translational selection acts as a weak additional factor influencing synonymous codon usage. These observations indicate that translational selection is a widespread phenomenon in vertebrates and is not limited to a few species.",
keywords = "genetic drift, mutational bias, synonymous codon usage, translational selection, vertebrates",
author = "James Mcinerney and Aoife Doherty and McInerney, {James O}",
year = "2013",
month = oct,
doi = "10.1093/molbev/mst128",
language = "English",
volume = "30",
journal = "Molecular Biology and Evolution",
issn = "1537-1719",
publisher = "Oxford University Press",
number = "10",

}

RIS

TY - JOUR

T1 - Translational selection frequently overcomes genetic drift in shaping synonymous codon usage patterns in vertebrates.

AU - Mcinerney, James

AU - Doherty, Aoife

AU - McInerney, James O

PY - 2013/10

Y1 - 2013/10

N2 - Synonymous codon usage patterns are shaped by a balance between mutation, drift, and natural selection. To date, detection of translational selection in vertebrates has proven to be a challenging task, obscured by small long-term effective population sizes in larger animals and the existence of isochores in some species. The consensus is that, in such species, natural selection is either completely ineffective at overcoming mutational pressures and genetic drift or perhaps is effective but so weak that it is not detectable. The aim of this research is to understand the interplay between mutation, selection, and genetic drift in vertebrates. We observe that although variation in mutational bias is undoubtedly the dominant force influencing codon usage, translational selection acts as a weak additional factor influencing synonymous codon usage. These observations indicate that translational selection is a widespread phenomenon in vertebrates and is not limited to a few species.

AB - Synonymous codon usage patterns are shaped by a balance between mutation, drift, and natural selection. To date, detection of translational selection in vertebrates has proven to be a challenging task, obscured by small long-term effective population sizes in larger animals and the existence of isochores in some species. The consensus is that, in such species, natural selection is either completely ineffective at overcoming mutational pressures and genetic drift or perhaps is effective but so weak that it is not detectable. The aim of this research is to understand the interplay between mutation, selection, and genetic drift in vertebrates. We observe that although variation in mutational bias is undoubtedly the dominant force influencing codon usage, translational selection acts as a weak additional factor influencing synonymous codon usage. These observations indicate that translational selection is a widespread phenomenon in vertebrates and is not limited to a few species.

KW - genetic drift

KW - mutational bias

KW - synonymous codon usage

KW - translational selection

KW - vertebrates

U2 - 10.1093/molbev/mst128

DO - 10.1093/molbev/mst128

M3 - Article

C2 - 23883522

VL - 30

JO - Molecular Biology and Evolution

JF - Molecular Biology and Evolution

SN - 1537-1719

IS - 10

ER -