Transition-metal-free direct arylation of anilines

Research output: Contribution to journalArticle

  • External authors:
  • Tracey Pirali
  • Fengzhi Zhang
  • Anna H. Miller
  • Jenna L. Head
  • Donald McAusland


Aryne arylation: A new method of direct arylation is reported for aniline substrates. The reaction uses benzyne to synthesize a variety of aminobiaryls under mild conditions (see scheme), requiring no stoichiometric metalation or transition-metal catalysis. An ene mechanism is implicated, and conveys excellent functional group tolerance relative to metal-mediated processes. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographical metadata

Original languageEnglish
Pages (from-to)1006-1009
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number4
StatePublished - 23 Jan 2012