Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biologyCitation formats

  • External authors:
  • Balázs I. Tóth
  • Tamás Géczy
  • Zoltán Griger
  • Anikó Dózsa
  • Holger Seltmann
  • László Kovács
  • László Nagy
  • Christos C. Zouboulis
  • Tamás Bíró

Standard

Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biology. / Tóth, Balázs I.; Géczy, Tamás; Griger, Zoltán; Dózsa, Anikó; Seltmann, Holger; Kovács, László; Nagy, László; Zouboulis, Christos C.; Paus, Ralf; Bíró, Tamás.

In: Journal of Investigative Dermatology, Vol. 129, No. 2, 02.2009, p. 329-339.

Research output: Contribution to journalArticle

Harvard

Tóth, BI, Géczy, T, Griger, Z, Dózsa, A, Seltmann, H, Kovács, L, Nagy, L, Zouboulis, CC, Paus, R & Bíró, T 2009, 'Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biology', Journal of Investigative Dermatology, vol. 129, no. 2, pp. 329-339. https://doi.org/10.1038/jid.2008.258

APA

Tóth, B. I., Géczy, T., Griger, Z., Dózsa, A., Seltmann, H., Kovács, L., ... Bíró, T. (2009). Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biology. Journal of Investigative Dermatology, 129(2), 329-339. https://doi.org/10.1038/jid.2008.258

Vancouver

Tóth BI, Géczy T, Griger Z, Dózsa A, Seltmann H, Kovács L et al. Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biology. Journal of Investigative Dermatology. 2009 Feb;129(2):329-339. https://doi.org/10.1038/jid.2008.258

Author

Tóth, Balázs I. ; Géczy, Tamás ; Griger, Zoltán ; Dózsa, Anikó ; Seltmann, Holger ; Kovács, László ; Nagy, László ; Zouboulis, Christos C. ; Paus, Ralf ; Bíró, Tamás. / Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biology. In: Journal of Investigative Dermatology. 2009 ; Vol. 129, No. 2. pp. 329-339.

Bibtex

@article{ca076044fb2c4c1491b58a42765156a6,
title = "Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biology",
abstract = "Transient receptor potential vanilloid-1 (TRPV1), originally described as a central integrator of nociception, is expressed on human epidermal and hair follicle keratinocytes and is involved in regulation of cell growth and death. In human pilosebaceous units, we had shown that TRPV1 stimulation inhibits hair shaft elongation and matrix keratinocyte proliferation, and induces premature hair follicle regression and keratinocyte apoptosis. In the current study, we have explored the role of TRPV1-mediated signaling in sebaceous gland (SG) biology, using a human sebocyte cell culture model (SZ95 sebocytes). Demonstrating that human skin SG in situ and SZ95 sebocytes in vitro express TRPV1, we show that the prototypic TRPV1 agonist, capsaicin, selectively inhibits basal and arachidonic acid-induced lipid synthesis in a dose-, time-, and extracellular calcium-dependent and a TRPV1-specific manner. Low-dose capsaicin stimulates cellular proliferation via TRPV1, whereas higher concentrations inhibit sebocyte growth and induce cell death independent of TRPV1. Moreover, capsaicin suppresses the expression of genes involved in lipid homeostasis and of selected proinflammatory cytokines. Collectively, these findings support the concept that TRPV1 signaling is a significant, previously unreported player in human sebocyte biology and identify TRPV1 as a promising target in the clinical management of inflammatory SG disorders (for example, acne vulgaris). {\circledC} 2009 The Society for Investigative Dermatology.",
author = "T{\'o}th, {Bal{\'a}zs I.} and Tam{\'a}s G{\'e}czy and Zolt{\'a}n Griger and Anik{\'o} D{\'o}zsa and Holger Seltmann and L{\'a}szl{\'o} Kov{\'a}cs and L{\'a}szl{\'o} Nagy and Zouboulis, {Christos C.} and Ralf Paus and Tam{\'a}s B{\'i}r{\'o}",
year = "2009",
month = "2",
doi = "10.1038/jid.2008.258",
language = "English",
volume = "129",
pages = "329--339",
journal = "The Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Springer Nature",
number = "2",

}

RIS

TY - JOUR

T1 - Transient receptor potential vanilloid-1 signaling as a regulator of human sebocyte biology

AU - Tóth, Balázs I.

AU - Géczy, Tamás

AU - Griger, Zoltán

AU - Dózsa, Anikó

AU - Seltmann, Holger

AU - Kovács, László

AU - Nagy, László

AU - Zouboulis, Christos C.

AU - Paus, Ralf

AU - Bíró, Tamás

PY - 2009/2

Y1 - 2009/2

N2 - Transient receptor potential vanilloid-1 (TRPV1), originally described as a central integrator of nociception, is expressed on human epidermal and hair follicle keratinocytes and is involved in regulation of cell growth and death. In human pilosebaceous units, we had shown that TRPV1 stimulation inhibits hair shaft elongation and matrix keratinocyte proliferation, and induces premature hair follicle regression and keratinocyte apoptosis. In the current study, we have explored the role of TRPV1-mediated signaling in sebaceous gland (SG) biology, using a human sebocyte cell culture model (SZ95 sebocytes). Demonstrating that human skin SG in situ and SZ95 sebocytes in vitro express TRPV1, we show that the prototypic TRPV1 agonist, capsaicin, selectively inhibits basal and arachidonic acid-induced lipid synthesis in a dose-, time-, and extracellular calcium-dependent and a TRPV1-specific manner. Low-dose capsaicin stimulates cellular proliferation via TRPV1, whereas higher concentrations inhibit sebocyte growth and induce cell death independent of TRPV1. Moreover, capsaicin suppresses the expression of genes involved in lipid homeostasis and of selected proinflammatory cytokines. Collectively, these findings support the concept that TRPV1 signaling is a significant, previously unreported player in human sebocyte biology and identify TRPV1 as a promising target in the clinical management of inflammatory SG disorders (for example, acne vulgaris). © 2009 The Society for Investigative Dermatology.

AB - Transient receptor potential vanilloid-1 (TRPV1), originally described as a central integrator of nociception, is expressed on human epidermal and hair follicle keratinocytes and is involved in regulation of cell growth and death. In human pilosebaceous units, we had shown that TRPV1 stimulation inhibits hair shaft elongation and matrix keratinocyte proliferation, and induces premature hair follicle regression and keratinocyte apoptosis. In the current study, we have explored the role of TRPV1-mediated signaling in sebaceous gland (SG) biology, using a human sebocyte cell culture model (SZ95 sebocytes). Demonstrating that human skin SG in situ and SZ95 sebocytes in vitro express TRPV1, we show that the prototypic TRPV1 agonist, capsaicin, selectively inhibits basal and arachidonic acid-induced lipid synthesis in a dose-, time-, and extracellular calcium-dependent and a TRPV1-specific manner. Low-dose capsaicin stimulates cellular proliferation via TRPV1, whereas higher concentrations inhibit sebocyte growth and induce cell death independent of TRPV1. Moreover, capsaicin suppresses the expression of genes involved in lipid homeostasis and of selected proinflammatory cytokines. Collectively, these findings support the concept that TRPV1 signaling is a significant, previously unreported player in human sebocyte biology and identify TRPV1 as a promising target in the clinical management of inflammatory SG disorders (for example, acne vulgaris). © 2009 The Society for Investigative Dermatology.

U2 - 10.1038/jid.2008.258

DO - 10.1038/jid.2008.258

M3 - Article

VL - 129

SP - 329

EP - 339

JO - The Journal of Investigative Dermatology

JF - The Journal of Investigative Dermatology

SN - 0022-202X

IS - 2

ER -