Tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European populationCitation formats

  • External authors:
  • L. Lo
  • H. Valentine
  • J. Harrison
  • S. Hayes
  • I. Welch
  • S. Pritchard

Standard

Tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European population. / Lo, L.; Valentine, H.; Harrison, J.; Hayes, S.; Welch, I.; Pritchard, S.; West, C.; Ang, Y.

In: British Journal of Cancer, Vol. 107, No. 7, 25.09.2012, p. 1125-1130.

Research output: Contribution to journalArticle

Harvard

Lo, L, Valentine, H, Harrison, J, Hayes, S, Welch, I, Pritchard, S, West, C & Ang, Y 2012, 'Tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European population', British Journal of Cancer, vol. 107, no. 7, pp. 1125-1130. https://doi.org/10.1038/bjc.2012.363

APA

Lo, L., Valentine, H., Harrison, J., Hayes, S., Welch, I., Pritchard, S., ... Ang, Y. (2012). Tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European population. British Journal of Cancer, 107(7), 1125-1130. https://doi.org/10.1038/bjc.2012.363

Vancouver

Lo L, Valentine H, Harrison J, Hayes S, Welch I, Pritchard S et al. Tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European population. British Journal of Cancer. 2012 Sep 25;107(7):1125-1130. https://doi.org/10.1038/bjc.2012.363

Author

Lo, L. ; Valentine, H. ; Harrison, J. ; Hayes, S. ; Welch, I. ; Pritchard, S. ; West, C. ; Ang, Y. / Tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European population. In: British Journal of Cancer. 2012 ; Vol. 107, No. 7. pp. 1125-1130.

Bibtex

@article{d54b6cda397040aba934e6e0ce41a9f9,
title = "Tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European population",
abstract = "Background: Tissue factor (TF), which has a role in normal tissue haemostasis, was reported to be aberrantly expressed, associated with higher microvascular density and a poor prognosis in intestinal-type gastric adenocarcinoma in the Japanese population. This is the first study to look at the relationship of TF and the metaplasia-adenoma-carcinoma sequence (MACS) of gastric cancer in a European population. Methods: The expression of TF was examined immunohistochemically in 191 gastric tissue samples: (13: normal; 18: intestinal metaplasia; 160: gastric adenocarcinoma) from the European population. Results: TF was not expressed in normal gastric mucosal cells. A strong intensity of staining was found in intestinal metaplasia cells but in 2 of 18 samples. TF expression increased with advancing stage of gastric cancer (P=0.0001, Jonckheeres test for ordered medians). Stage 3-4 gastric cancers preferentially expressed TF (34{\%}, P=0.04). In comparison with the Japanese study, TF was not expressed at a higher level in intestinal vs diffuse-type gastric cancers and expression had no prognostic significance.Conclusion:TF may be involved in tumour progression along the MACS of gastric cancer in the European population and is shown to start in precancerous lesions. However, clinical features may differ due to differences in biological features in the two populations, as reflected by differences in TF expression profile. {\circledC} 2012 Cancer Research UK All rights reserved.",
keywords = "gastric adenocarcinoma, metaplasia-adenoma-carcinoma sequence, tissue factor",
author = "L. Lo and H. Valentine and J. Harrison and S. Hayes and I. Welch and S. Pritchard and C. West and Y. Ang",
year = "2012",
month = "9",
day = "25",
doi = "10.1038/bjc.2012.363",
language = "English",
volume = "107",
pages = "1125--1130",
journal = "BJC",
issn = "0007-0920",
publisher = "Springer Nature",
number = "7",

}

RIS

TY - JOUR

T1 - Tissue factor expression in the metaplasia–adenoma–carcinoma sequence of gastric cancer in a European population

AU - Lo, L.

AU - Valentine, H.

AU - Harrison, J.

AU - Hayes, S.

AU - Welch, I.

AU - Pritchard, S.

AU - West, C.

AU - Ang, Y.

PY - 2012/9/25

Y1 - 2012/9/25

N2 - Background: Tissue factor (TF), which has a role in normal tissue haemostasis, was reported to be aberrantly expressed, associated with higher microvascular density and a poor prognosis in intestinal-type gastric adenocarcinoma in the Japanese population. This is the first study to look at the relationship of TF and the metaplasia-adenoma-carcinoma sequence (MACS) of gastric cancer in a European population. Methods: The expression of TF was examined immunohistochemically in 191 gastric tissue samples: (13: normal; 18: intestinal metaplasia; 160: gastric adenocarcinoma) from the European population. Results: TF was not expressed in normal gastric mucosal cells. A strong intensity of staining was found in intestinal metaplasia cells but in 2 of 18 samples. TF expression increased with advancing stage of gastric cancer (P=0.0001, Jonckheeres test for ordered medians). Stage 3-4 gastric cancers preferentially expressed TF (34%, P=0.04). In comparison with the Japanese study, TF was not expressed at a higher level in intestinal vs diffuse-type gastric cancers and expression had no prognostic significance.Conclusion:TF may be involved in tumour progression along the MACS of gastric cancer in the European population and is shown to start in precancerous lesions. However, clinical features may differ due to differences in biological features in the two populations, as reflected by differences in TF expression profile. © 2012 Cancer Research UK All rights reserved.

AB - Background: Tissue factor (TF), which has a role in normal tissue haemostasis, was reported to be aberrantly expressed, associated with higher microvascular density and a poor prognosis in intestinal-type gastric adenocarcinoma in the Japanese population. This is the first study to look at the relationship of TF and the metaplasia-adenoma-carcinoma sequence (MACS) of gastric cancer in a European population. Methods: The expression of TF was examined immunohistochemically in 191 gastric tissue samples: (13: normal; 18: intestinal metaplasia; 160: gastric adenocarcinoma) from the European population. Results: TF was not expressed in normal gastric mucosal cells. A strong intensity of staining was found in intestinal metaplasia cells but in 2 of 18 samples. TF expression increased with advancing stage of gastric cancer (P=0.0001, Jonckheeres test for ordered medians). Stage 3-4 gastric cancers preferentially expressed TF (34%, P=0.04). In comparison with the Japanese study, TF was not expressed at a higher level in intestinal vs diffuse-type gastric cancers and expression had no prognostic significance.Conclusion:TF may be involved in tumour progression along the MACS of gastric cancer in the European population and is shown to start in precancerous lesions. However, clinical features may differ due to differences in biological features in the two populations, as reflected by differences in TF expression profile. © 2012 Cancer Research UK All rights reserved.

KW - gastric adenocarcinoma

KW - metaplasia-adenoma-carcinoma sequence

KW - tissue factor

U2 - 10.1038/bjc.2012.363

DO - 10.1038/bjc.2012.363

M3 - Article

VL - 107

SP - 1125

EP - 1130

JO - BJC

JF - BJC

SN - 0007-0920

IS - 7

ER -