The role of neuropeptides in psoriasis

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The pathogenesis of psoriasis is incompletely understood but cutaneous neurogenic inflammation is probably involved. This involvement is suggested by a number of clinical and histological observations. Reports about the distribution of cutaneous nerves and the quantification of nerve growth factor and neuropeptides, including calcitonin gene-related peptide and vasoactive intestinal peptide, in lesional and nonlesional psoriatic skin suggest that sensory neuropeptides contribute to the development of psoriasis. This review summarizes what is known about the role of neurogenic markers in psoriasis. © 2006 The Authors.

Bibliographical metadata

Original languageEnglish
Pages (from-to)876-882
Number of pages6
JournalBritish Journal of Dermatology
Issue number5
Publication statusPublished - Nov 2006