The prognostic value of dynamic contrast-enhanced MRI contrast agent transfer constant Ktrans in cervical cancer is explained by plasma flow rather than vessel permeabilityCitation formats

  • External authors:
  • Chris J. Rose
  • Lucy E. Kershaw
  • Stephanie B Withey
  • Bernadette M Carrington
  • Susan E. Davidson
  • Gillian Hutchison

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The prognostic value of dynamic contrast-enhanced MRI contrast agent transfer constant Ktrans in cervical cancer is explained by plasma flow rather than vessel permeability. / Dickie, Ben R.; Rose, Chris J.; Kershaw, Lucy E.; Withey, Stephanie B; Carrington, Bernadette M; Davidson, Susan E.; Hutchison, Gillian; West, Catharine M.L.

In: British Journal of Cancer, Vol. 116, No. 11, 2017, p. 1436-1443.

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Dickie, Ben R. ; Rose, Chris J. ; Kershaw, Lucy E. ; Withey, Stephanie B ; Carrington, Bernadette M ; Davidson, Susan E. ; Hutchison, Gillian ; West, Catharine M.L. / The prognostic value of dynamic contrast-enhanced MRI contrast agent transfer constant Ktrans in cervical cancer is explained by plasma flow rather than vessel permeability. In: British Journal of Cancer. 2017 ; Vol. 116, No. 11. pp. 1436-1443.

Bibtex

@article{bfd09128e10f441fa34d948745af37a1,
title = "The prognostic value of dynamic contrast-enhanced MRI contrast agent transfer constant Ktrans in cervical cancer is explained by plasma flow rather than vessel permeability",
abstract = "Background: The microvascular contrast agent transfer constant Ktrans has shown prognostic value in cervical cancer patients treated with chemoradiotherapy. This study aims to determine whether this is explained by the contribution to Ktrans of plasma flow (Fp), vessel permeability surface-area product (PS), or a combination of both.Methods: Pre-treatment dynamic contrast-enhanced MRI (DCE-MRI) data from 36 patients were analysed using the two-compartment exchange model. Estimates of Fp, PS, Ktrans, and fractional plasma and interstitial volumes (vp and ve) were made and used in univariate and multivariate survival analyses adjusting for clinicopathologic variables tumour stage, nodal status, histological subtype, patient age, tumour volume, and treatment type (chemoradiotherapy vs radiotherapy alone). Results: In univariate analyses, Fp (HR=0.25, P=0.0095) and Ktrans (HR=0.20, P=0.032) were significantly associated with disease-free survival while PS, vp and ve were not. In multivariate analyses adjusting for clinicopathologic variables, Fp and Ktrans significantly increased the accuracy of survival predictions (P=0.0089).Conclusions: The prognostic value of Ktrans in cervical cancer patients treated with chemoradiotherapy is explained by microvascular plasma flow (Fp) rather than vessel permeability surface-area product (PS).",
keywords = "Cervix cancer, DCE-MRI, K, Permeability surface-area product, Plasma flow, Prognostic biomarker",
author = "Dickie, {Ben R.} and Rose, {Chris J.} and Kershaw, {Lucy E.} and Withey, {Stephanie B} and Carrington, {Bernadette M} and Davidson, {Susan E.} and Gillian Hutchison and West, {Catharine M.L.}",
year = "2017",
doi = "10.1038/bjc.2017.121",
language = "English",
volume = "116",
pages = "1436--1443",
journal = "BJC",
issn = "0007-0920",
publisher = "Springer Nature",
number = "11",

}

RIS

TY - JOUR

T1 - The prognostic value of dynamic contrast-enhanced MRI contrast agent transfer constant Ktrans in cervical cancer is explained by plasma flow rather than vessel permeability

AU - Dickie, Ben R.

AU - Rose, Chris J.

AU - Kershaw, Lucy E.

AU - Withey, Stephanie B

AU - Carrington, Bernadette M

AU - Davidson, Susan E.

AU - Hutchison, Gillian

AU - West, Catharine M.L.

PY - 2017

Y1 - 2017

N2 - Background: The microvascular contrast agent transfer constant Ktrans has shown prognostic value in cervical cancer patients treated with chemoradiotherapy. This study aims to determine whether this is explained by the contribution to Ktrans of plasma flow (Fp), vessel permeability surface-area product (PS), or a combination of both.Methods: Pre-treatment dynamic contrast-enhanced MRI (DCE-MRI) data from 36 patients were analysed using the two-compartment exchange model. Estimates of Fp, PS, Ktrans, and fractional plasma and interstitial volumes (vp and ve) were made and used in univariate and multivariate survival analyses adjusting for clinicopathologic variables tumour stage, nodal status, histological subtype, patient age, tumour volume, and treatment type (chemoradiotherapy vs radiotherapy alone). Results: In univariate analyses, Fp (HR=0.25, P=0.0095) and Ktrans (HR=0.20, P=0.032) were significantly associated with disease-free survival while PS, vp and ve were not. In multivariate analyses adjusting for clinicopathologic variables, Fp and Ktrans significantly increased the accuracy of survival predictions (P=0.0089).Conclusions: The prognostic value of Ktrans in cervical cancer patients treated with chemoradiotherapy is explained by microvascular plasma flow (Fp) rather than vessel permeability surface-area product (PS).

AB - Background: The microvascular contrast agent transfer constant Ktrans has shown prognostic value in cervical cancer patients treated with chemoradiotherapy. This study aims to determine whether this is explained by the contribution to Ktrans of plasma flow (Fp), vessel permeability surface-area product (PS), or a combination of both.Methods: Pre-treatment dynamic contrast-enhanced MRI (DCE-MRI) data from 36 patients were analysed using the two-compartment exchange model. Estimates of Fp, PS, Ktrans, and fractional plasma and interstitial volumes (vp and ve) were made and used in univariate and multivariate survival analyses adjusting for clinicopathologic variables tumour stage, nodal status, histological subtype, patient age, tumour volume, and treatment type (chemoradiotherapy vs radiotherapy alone). Results: In univariate analyses, Fp (HR=0.25, P=0.0095) and Ktrans (HR=0.20, P=0.032) were significantly associated with disease-free survival while PS, vp and ve were not. In multivariate analyses adjusting for clinicopathologic variables, Fp and Ktrans significantly increased the accuracy of survival predictions (P=0.0089).Conclusions: The prognostic value of Ktrans in cervical cancer patients treated with chemoradiotherapy is explained by microvascular plasma flow (Fp) rather than vessel permeability surface-area product (PS).

KW - Cervix cancer

KW - DCE-MRI

KW - K

KW - Permeability surface-area product

KW - Plasma flow

KW - Prognostic biomarker

UR - http://www.scopus.com/inward/record.url?scp=85019936132&partnerID=8YFLogxK

U2 - 10.1038/bjc.2017.121

DO - 10.1038/bjc.2017.121

M3 - Article

AN - SCOPUS:85019936132

VL - 116

SP - 1436

EP - 1443

JO - BJC

JF - BJC

SN - 0007-0920

IS - 11

ER -