The neural basis of conceptual-emotional integration and its role in major depressive disorderCitation formats

  • External authors:
  • Sophie Green
  • Jorge Moll
  • Jessica Zakrzewski
  • Jordan Grafman
  • Roland Zahn

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The neural basis of conceptual-emotional integration and its role in major depressive disorder. / Green, Sophie; Lambon Ralph, Matthew A.; Moll, Jorge; Zakrzewski, Jessica; Deakin, John F William; Grafman, Jordan; Zahn, Roland; Haggis, Beverley.

In: Social Neuroscience, Vol. 8, No. 5, 09.2013, p. 417-433.

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Green, Sophie ; Lambon Ralph, Matthew A. ; Moll, Jorge ; Zakrzewski, Jessica ; Deakin, John F William ; Grafman, Jordan ; Zahn, Roland ; Haggis, Beverley. / The neural basis of conceptual-emotional integration and its role in major depressive disorder. In: Social Neuroscience. 2013 ; Vol. 8, No. 5. pp. 417-433.

Bibtex

@article{a861126605f74b7b8e549b13e380d742,
title = "The neural basis of conceptual-emotional integration and its role in major depressive disorder",
abstract = "The importance of differentiating between social concepts when appraising actions (e.g., understanding behavior as critical vs. fault-finding) and its contribution to vulnerability to major depressive disorder (MDD) is unknown. We predicted poor integration of differentiated conceptual knowledge when people with MDD appraise their social actions, contributing to their tendency to grossly overgeneralize self-blame (e.g., {"}I am unlikable rather than critical{"}). To test this hypothesis, we used a neuropsychological test measuring social conceptual differentiation and its relationship with emotional biases in a remitted MDD and a control group. During fMRI, guilt- and indignation-evoking sentences were presented. As predicted, conceptual overgeneralization was associated with increased emotional intensity when appraising social actions. Interdependence of conceptual overgeneralization and negative emotional biases was stronger in MDD (reproducible in the subgroup without medication) and was associated with overgeneralized self-blame. This high conceptual-emotional interdependence was associated with functional disconnection between the right superior anterior temporal lobe (ATL) and right dorsolateral prefrontal cortex (PFC) as well as a septal region across groups when experiencing guilt (SPM8). Strong coupling of conceptual information (ATL) with information about the context of actions and emotions (frontal-subcortical regions) is thus associated with appraisal being less dependent on conceptual overgeneralization, thereby protecting against excessive self-blame. {\circledC} 2013 Copyright 2013 The Author(s). Published by Taylor & Francis.",
keywords = "Differentiation, Emotional biases, Information theory, Major depression, Moral emotions, Overgeneralization, Redundancy, Self-blame, Social concepts, Vulnerability",
author = "Sophie Green and {Lambon Ralph}, {Matthew A.} and Jorge Moll and Jessica Zakrzewski and Deakin, {John F William} and Jordan Grafman and Roland Zahn and Beverley Haggis",
note = "G0902304, Medical Research Council, United KingdomZIA NS002792-21, NINDS NIH HHS, United States",
year = "2013",
month = "9",
doi = "10.1080/17470919.2013.810171",
language = "English",
volume = "8",
pages = "417--433",
journal = "Social Neuroscience",
issn = "1747-0919",
publisher = "Psychology Press Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - The neural basis of conceptual-emotional integration and its role in major depressive disorder

AU - Green, Sophie

AU - Lambon Ralph, Matthew A.

AU - Moll, Jorge

AU - Zakrzewski, Jessica

AU - Deakin, John F William

AU - Grafman, Jordan

AU - Zahn, Roland

AU - Haggis, Beverley

N1 - G0902304, Medical Research Council, United KingdomZIA NS002792-21, NINDS NIH HHS, United States

PY - 2013/9

Y1 - 2013/9

N2 - The importance of differentiating between social concepts when appraising actions (e.g., understanding behavior as critical vs. fault-finding) and its contribution to vulnerability to major depressive disorder (MDD) is unknown. We predicted poor integration of differentiated conceptual knowledge when people with MDD appraise their social actions, contributing to their tendency to grossly overgeneralize self-blame (e.g., "I am unlikable rather than critical"). To test this hypothesis, we used a neuropsychological test measuring social conceptual differentiation and its relationship with emotional biases in a remitted MDD and a control group. During fMRI, guilt- and indignation-evoking sentences were presented. As predicted, conceptual overgeneralization was associated with increased emotional intensity when appraising social actions. Interdependence of conceptual overgeneralization and negative emotional biases was stronger in MDD (reproducible in the subgroup without medication) and was associated with overgeneralized self-blame. This high conceptual-emotional interdependence was associated with functional disconnection between the right superior anterior temporal lobe (ATL) and right dorsolateral prefrontal cortex (PFC) as well as a septal region across groups when experiencing guilt (SPM8). Strong coupling of conceptual information (ATL) with information about the context of actions and emotions (frontal-subcortical regions) is thus associated with appraisal being less dependent on conceptual overgeneralization, thereby protecting against excessive self-blame. © 2013 Copyright 2013 The Author(s). Published by Taylor & Francis.

AB - The importance of differentiating between social concepts when appraising actions (e.g., understanding behavior as critical vs. fault-finding) and its contribution to vulnerability to major depressive disorder (MDD) is unknown. We predicted poor integration of differentiated conceptual knowledge when people with MDD appraise their social actions, contributing to their tendency to grossly overgeneralize self-blame (e.g., "I am unlikable rather than critical"). To test this hypothesis, we used a neuropsychological test measuring social conceptual differentiation and its relationship with emotional biases in a remitted MDD and a control group. During fMRI, guilt- and indignation-evoking sentences were presented. As predicted, conceptual overgeneralization was associated with increased emotional intensity when appraising social actions. Interdependence of conceptual overgeneralization and negative emotional biases was stronger in MDD (reproducible in the subgroup without medication) and was associated with overgeneralized self-blame. This high conceptual-emotional interdependence was associated with functional disconnection between the right superior anterior temporal lobe (ATL) and right dorsolateral prefrontal cortex (PFC) as well as a septal region across groups when experiencing guilt (SPM8). Strong coupling of conceptual information (ATL) with information about the context of actions and emotions (frontal-subcortical regions) is thus associated with appraisal being less dependent on conceptual overgeneralization, thereby protecting against excessive self-blame. © 2013 Copyright 2013 The Author(s). Published by Taylor & Francis.

KW - Differentiation

KW - Emotional biases

KW - Information theory

KW - Major depression

KW - Moral emotions

KW - Overgeneralization

KW - Redundancy

KW - Self-blame

KW - Social concepts

KW - Vulnerability

U2 - 10.1080/17470919.2013.810171

DO - 10.1080/17470919.2013.810171

M3 - Article

VL - 8

SP - 417

EP - 433

JO - Social Neuroscience

T2 - Social Neuroscience

JF - Social Neuroscience

SN - 1747-0919

IS - 5

ER -