The mineralocorticoid receptor as a novel player in skin biology: Beyond the renal horizon?Citation formats

  • External authors:
  • Nicolette Farman
  • Eve Maubec
  • Burkhard Poeggeler
  • Jennifer E. Klatte
  • Frederic Jaisser

Standard

The mineralocorticoid receptor as a novel player in skin biology: Beyond the renal horizon? / Farman, Nicolette; Maubec, Eve; Poeggeler, Burkhard; Klatte, Jennifer E.; Jaisser, Frederic; Paus, Ralf.

In: Experimental Dermatology, Vol. 19, No. 2, 02.2010, p. 100-107.

Research output: Contribution to journalArticle

Harvard

Farman, N, Maubec, E, Poeggeler, B, Klatte, JE, Jaisser, F & Paus, R 2010, 'The mineralocorticoid receptor as a novel player in skin biology: Beyond the renal horizon?', Experimental Dermatology, vol. 19, no. 2, pp. 100-107. https://doi.org/10.1111/j.1600-0625.2009.01011.x

APA

Farman, N., Maubec, E., Poeggeler, B., Klatte, J. E., Jaisser, F., & Paus, R. (2010). The mineralocorticoid receptor as a novel player in skin biology: Beyond the renal horizon? Experimental Dermatology, 19(2), 100-107. https://doi.org/10.1111/j.1600-0625.2009.01011.x

Vancouver

Farman N, Maubec E, Poeggeler B, Klatte JE, Jaisser F, Paus R. The mineralocorticoid receptor as a novel player in skin biology: Beyond the renal horizon? Experimental Dermatology. 2010 Feb;19(2):100-107. https://doi.org/10.1111/j.1600-0625.2009.01011.x

Author

Farman, Nicolette ; Maubec, Eve ; Poeggeler, Burkhard ; Klatte, Jennifer E. ; Jaisser, Frederic ; Paus, Ralf. / The mineralocorticoid receptor as a novel player in skin biology: Beyond the renal horizon?. In: Experimental Dermatology. 2010 ; Vol. 19, No. 2. pp. 100-107.

Bibtex

@article{8717739b9309429cb837ad2b2fff7de1,
title = "The mineralocorticoid receptor as a novel player in skin biology: Beyond the renal horizon?",
abstract = "The mineralocorticoid receptor (MR) and its ligand aldosterone regulate renal sodium reabsorption and blood pressure and much knowledge has been accumulated in MR physiopathology, cellular and molecular targets. In contrast, our understanding of this hormonal system in non-classical targets (heart, blood vessels, neurons, keratinocytes...) is limited, particularly in the mammalian skin. We review here the few available data that point on MR in the skin and that document cutaneous MR expression and function, based on mouse models and very limited observations in humans. Mice that overexpress the MR in the basal epidermal keratinocytes display developmental and post-natal abnormalities of the epidermis and hair follicle, raising exciting new questions regarding skin biology. The MR as a transcription factor may be an unexpected novel player in regulating keratinocyte and hair physiology and pathology. Because its activating ligand also includes glucocorticoids, that are widely used in dermatology, we propose that the MR may be also involved in the side-effects of corticoids, opening novel options for therapeutical intervention. {\circledC} 2009 John Wiley & Sons A/S.",
keywords = "Aldosterone, Epidermis, Glucocorticoid, Hair follicle",
author = "Nicolette Farman and Eve Maubec and Burkhard Poeggeler and Klatte, {Jennifer E.} and Frederic Jaisser and Ralf Paus",
year = "2010",
month = "2",
doi = "10.1111/j.1600-0625.2009.01011.x",
language = "English",
volume = "19",
pages = "100--107",
journal = "Experimental Dermatology",
issn = "1600-0625",
publisher = "John Wiley & Sons Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - The mineralocorticoid receptor as a novel player in skin biology: Beyond the renal horizon?

AU - Farman, Nicolette

AU - Maubec, Eve

AU - Poeggeler, Burkhard

AU - Klatte, Jennifer E.

AU - Jaisser, Frederic

AU - Paus, Ralf

PY - 2010/2

Y1 - 2010/2

N2 - The mineralocorticoid receptor (MR) and its ligand aldosterone regulate renal sodium reabsorption and blood pressure and much knowledge has been accumulated in MR physiopathology, cellular and molecular targets. In contrast, our understanding of this hormonal system in non-classical targets (heart, blood vessels, neurons, keratinocytes...) is limited, particularly in the mammalian skin. We review here the few available data that point on MR in the skin and that document cutaneous MR expression and function, based on mouse models and very limited observations in humans. Mice that overexpress the MR in the basal epidermal keratinocytes display developmental and post-natal abnormalities of the epidermis and hair follicle, raising exciting new questions regarding skin biology. The MR as a transcription factor may be an unexpected novel player in regulating keratinocyte and hair physiology and pathology. Because its activating ligand also includes glucocorticoids, that are widely used in dermatology, we propose that the MR may be also involved in the side-effects of corticoids, opening novel options for therapeutical intervention. © 2009 John Wiley & Sons A/S.

AB - The mineralocorticoid receptor (MR) and its ligand aldosterone regulate renal sodium reabsorption and blood pressure and much knowledge has been accumulated in MR physiopathology, cellular and molecular targets. In contrast, our understanding of this hormonal system in non-classical targets (heart, blood vessels, neurons, keratinocytes...) is limited, particularly in the mammalian skin. We review here the few available data that point on MR in the skin and that document cutaneous MR expression and function, based on mouse models and very limited observations in humans. Mice that overexpress the MR in the basal epidermal keratinocytes display developmental and post-natal abnormalities of the epidermis and hair follicle, raising exciting new questions regarding skin biology. The MR as a transcription factor may be an unexpected novel player in regulating keratinocyte and hair physiology and pathology. Because its activating ligand also includes glucocorticoids, that are widely used in dermatology, we propose that the MR may be also involved in the side-effects of corticoids, opening novel options for therapeutical intervention. © 2009 John Wiley & Sons A/S.

KW - Aldosterone

KW - Epidermis

KW - Glucocorticoid

KW - Hair follicle

U2 - 10.1111/j.1600-0625.2009.01011.x

DO - 10.1111/j.1600-0625.2009.01011.x

M3 - Article

VL - 19

SP - 100

EP - 107

JO - Experimental Dermatology

JF - Experimental Dermatology

SN - 1600-0625

IS - 2

ER -