The lack of correlation between proliferation (Ki-67, PCNA, LI, Tpot), p53 expression and radiosensitivity for head and neck cancersCitation formats

  • External authors:
  • T. Björk-Eriksson
  • E. Cvetskovska
  • M. Svensson
  • E. Karlsson
  • B. Magnusson
  • N. J. Slevin
  • S. Edström
  • C. Mercke

Standard

The lack of correlation between proliferation (Ki-67, PCNA, LI, Tpot), p53 expression and radiosensitivity for head and neck cancers. / Björk-Eriksson, T.; West, C. M L; Cvetskovska, E.; Svensson, M.; Karlsson, E.; Magnusson, B.; Slevin, N. J.; Edström, S.; Mercke, C.

In: British Journal of Cancer, Vol. 80, No. 9, 1999, p. 1400-1404.

Research output: Contribution to journalArticle

Harvard

Björk-Eriksson, T, West, CML, Cvetskovska, E, Svensson, M, Karlsson, E, Magnusson, B, Slevin, NJ, Edström, S & Mercke, C 1999, 'The lack of correlation between proliferation (Ki-67, PCNA, LI, Tpot), p53 expression and radiosensitivity for head and neck cancers', British Journal of Cancer, vol. 80, no. 9, pp. 1400-1404. https://doi.org/10.1038/sj.bjc.6690535

APA

Björk-Eriksson, T., West, C. M. L., Cvetskovska, E., Svensson, M., Karlsson, E., Magnusson, B., ... Mercke, C. (1999). The lack of correlation between proliferation (Ki-67, PCNA, LI, Tpot), p53 expression and radiosensitivity for head and neck cancers. British Journal of Cancer, 80(9), 1400-1404. https://doi.org/10.1038/sj.bjc.6690535

Vancouver

Björk-Eriksson T, West CML, Cvetskovska E, Svensson M, Karlsson E, Magnusson B et al. The lack of correlation between proliferation (Ki-67, PCNA, LI, Tpot), p53 expression and radiosensitivity for head and neck cancers. British Journal of Cancer. 1999;80(9):1400-1404. https://doi.org/10.1038/sj.bjc.6690535

Author

Björk-Eriksson, T. ; West, C. M L ; Cvetskovska, E. ; Svensson, M. ; Karlsson, E. ; Magnusson, B. ; Slevin, N. J. ; Edström, S. ; Mercke, C. / The lack of correlation between proliferation (Ki-67, PCNA, LI, Tpot), p53 expression and radiosensitivity for head and neck cancers. In: British Journal of Cancer. 1999 ; Vol. 80, No. 9. pp. 1400-1404.

Bibtex

@article{e9fae4198d034aa7bf1877a2997d577f,
title = "The lack of correlation between proliferation (Ki-67, PCNA, LI, Tpot), p53 expression and radiosensitivity for head and neck cancers",
abstract = "A study was made of the relationship between measurements of radiosensitivity versus proliferation and p53 status in head and neck cancers. Inherent tumour radiosensitivity was assessed as surviving fraction at 2 Gy (SF2) using a clonogenic soft agar assay (n = 77). The results were compared to data on proliferation obtained by both flow cytometry (labelling index (LI), the potential doubling time (Tpot) n = 55) and immunohistochemistry (Ki-67 and PCNA; n = 68), together with immunohistochemical p53 expression (n = 68). There were no overall significant differences in the median values of the various parameters analysed for the different sites within the head and neck region, disease stages, grades of tumour differentiation or nodal states. A subgroup analysis showed that oropharyngeal (n = 22) versus oral cavity (n = 35) tumours were more radiosensitive (P = 0.056) and had a higher Ki-67 index (P = 0.001). Node-positive tumours had higher LI (P = 0.021) and a trend towards lower Tpot (P = 0.067) values than node-negative ones. No correlations were seen between SF2 and any of the parameters studied. The long-standing dogma of an increased radiosensitivity of rapidly proliferating cells in contrast to slowly proliferating cells was not confirmed. The study shows that parallel measurements of different biological markers can be obtained for a large number of patients with head and neck cancers. The independence of the various parameters studied suggests that there may be potential for their combined use as prognostic factors for the outcome of radiotherapy.",
keywords = "Head and neck cancer, p53, Proliferation, Radiosensitivity",
author = "T. Bj{\"o}rk-Eriksson and West, {C. M L} and E. Cvetskovska and M. Svensson and E. Karlsson and B. Magnusson and Slevin, {N. J.} and S. Edstr{\"o}m and C. Mercke",
year = "1999",
doi = "10.1038/sj.bjc.6690535",
language = "English",
volume = "80",
pages = "1400--1404",
journal = "BJC",
issn = "0007-0920",
publisher = "Springer Nature",
number = "9",

}

RIS

TY - JOUR

T1 - The lack of correlation between proliferation (Ki-67, PCNA, LI, Tpot), p53 expression and radiosensitivity for head and neck cancers

AU - Björk-Eriksson, T.

AU - West, C. M L

AU - Cvetskovska, E.

AU - Svensson, M.

AU - Karlsson, E.

AU - Magnusson, B.

AU - Slevin, N. J.

AU - Edström, S.

AU - Mercke, C.

PY - 1999

Y1 - 1999

N2 - A study was made of the relationship between measurements of radiosensitivity versus proliferation and p53 status in head and neck cancers. Inherent tumour radiosensitivity was assessed as surviving fraction at 2 Gy (SF2) using a clonogenic soft agar assay (n = 77). The results were compared to data on proliferation obtained by both flow cytometry (labelling index (LI), the potential doubling time (Tpot) n = 55) and immunohistochemistry (Ki-67 and PCNA; n = 68), together with immunohistochemical p53 expression (n = 68). There were no overall significant differences in the median values of the various parameters analysed for the different sites within the head and neck region, disease stages, grades of tumour differentiation or nodal states. A subgroup analysis showed that oropharyngeal (n = 22) versus oral cavity (n = 35) tumours were more radiosensitive (P = 0.056) and had a higher Ki-67 index (P = 0.001). Node-positive tumours had higher LI (P = 0.021) and a trend towards lower Tpot (P = 0.067) values than node-negative ones. No correlations were seen between SF2 and any of the parameters studied. The long-standing dogma of an increased radiosensitivity of rapidly proliferating cells in contrast to slowly proliferating cells was not confirmed. The study shows that parallel measurements of different biological markers can be obtained for a large number of patients with head and neck cancers. The independence of the various parameters studied suggests that there may be potential for their combined use as prognostic factors for the outcome of radiotherapy.

AB - A study was made of the relationship between measurements of radiosensitivity versus proliferation and p53 status in head and neck cancers. Inherent tumour radiosensitivity was assessed as surviving fraction at 2 Gy (SF2) using a clonogenic soft agar assay (n = 77). The results were compared to data on proliferation obtained by both flow cytometry (labelling index (LI), the potential doubling time (Tpot) n = 55) and immunohistochemistry (Ki-67 and PCNA; n = 68), together with immunohistochemical p53 expression (n = 68). There were no overall significant differences in the median values of the various parameters analysed for the different sites within the head and neck region, disease stages, grades of tumour differentiation or nodal states. A subgroup analysis showed that oropharyngeal (n = 22) versus oral cavity (n = 35) tumours were more radiosensitive (P = 0.056) and had a higher Ki-67 index (P = 0.001). Node-positive tumours had higher LI (P = 0.021) and a trend towards lower Tpot (P = 0.067) values than node-negative ones. No correlations were seen between SF2 and any of the parameters studied. The long-standing dogma of an increased radiosensitivity of rapidly proliferating cells in contrast to slowly proliferating cells was not confirmed. The study shows that parallel measurements of different biological markers can be obtained for a large number of patients with head and neck cancers. The independence of the various parameters studied suggests that there may be potential for their combined use as prognostic factors for the outcome of radiotherapy.

KW - Head and neck cancer

KW - p53

KW - Proliferation

KW - Radiosensitivity

U2 - 10.1038/sj.bjc.6690535

DO - 10.1038/sj.bjc.6690535

M3 - Article

VL - 80

SP - 1400

EP - 1404

JO - BJC

JF - BJC

SN - 0007-0920

IS - 9

ER -