The Feasibility and Effectiveness of PASS Plus, A Lay Health Worker Delivered Comprehensive Intervention for Autism Spectrum Disorders: Pilot RCT in a Rural Low and Middle Income Country SettingCitation formats

  • External authors:
  • Gauri Divan
  • Vivek Vajaratkar
  • Percy Cardozo
  • S Huzurbazar
  • M Verma
  • Elizabeth Howarth
  • Richard Emsley
  • Carol Taylor
  • Vikram Patel

Standard

The Feasibility and Effectiveness of PASS Plus, A Lay Health Worker Delivered Comprehensive Intervention for Autism Spectrum Disorders: Pilot RCT in a Rural Low and Middle Income Country Setting. / Divan, Gauri; Vajaratkar, Vivek; Cardozo, Percy; Huzurbazar, S; Verma, M; Howarth, Elizabeth; Emsley, Richard; Taylor, Carol; Patel, Vikram ; Green, Jonathan.

In: Autism research : official journal of the International Society for Autism Research, 01.02.2019.

Research output: Contribution to journalArticlepeer-review

Harvard

Divan, G, Vajaratkar, V, Cardozo, P, Huzurbazar, S, Verma, M, Howarth, E, Emsley, R, Taylor, C, Patel, V & Green, J 2019, 'The Feasibility and Effectiveness of PASS Plus, A Lay Health Worker Delivered Comprehensive Intervention for Autism Spectrum Disorders: Pilot RCT in a Rural Low and Middle Income Country Setting', Autism research : official journal of the International Society for Autism Research. https://doi.org/10.1002/aur.1978

APA

Divan, G., Vajaratkar, V., Cardozo, P., Huzurbazar, S., Verma, M., Howarth, E., Emsley, R., Taylor, C., Patel, V., & Green, J. (2019). The Feasibility and Effectiveness of PASS Plus, A Lay Health Worker Delivered Comprehensive Intervention for Autism Spectrum Disorders: Pilot RCT in a Rural Low and Middle Income Country Setting. Autism research : official journal of the International Society for Autism Research. https://doi.org/10.1002/aur.1978

Vancouver

Divan G, Vajaratkar V, Cardozo P, Huzurbazar S, Verma M, Howarth E et al. The Feasibility and Effectiveness of PASS Plus, A Lay Health Worker Delivered Comprehensive Intervention for Autism Spectrum Disorders: Pilot RCT in a Rural Low and Middle Income Country Setting. Autism research : official journal of the International Society for Autism Research. 2019 Feb 1. https://doi.org/10.1002/aur.1978

Author

Divan, Gauri ; Vajaratkar, Vivek ; Cardozo, Percy ; Huzurbazar, S ; Verma, M ; Howarth, Elizabeth ; Emsley, Richard ; Taylor, Carol ; Patel, Vikram ; Green, Jonathan. / The Feasibility and Effectiveness of PASS Plus, A Lay Health Worker Delivered Comprehensive Intervention for Autism Spectrum Disorders: Pilot RCT in a Rural Low and Middle Income Country Setting. In: Autism research : official journal of the International Society for Autism Research. 2019.

Bibtex

@article{c455455e6db64e4da078c8da078c1fc5,
title = "The Feasibility and Effectiveness of PASS Plus, A Lay Health Worker Delivered Comprehensive Intervention for Autism Spectrum Disorders: Pilot RCT in a Rural Low and Middle Income Country Setting",
abstract = "The treatment gap for autism globally is high. Our previous PASS intervention, delivered by community based lay health workers, showed effectiveness. This article reports the development and evaluation of a new {"}PASS 'Plus'{"} intervention in a rural population in India. Using formative research methods, we supplemented the PASS intervention with additional (Plus) modules to address autism comorbidities. This is the first time that a rigorous methodology has been used to evaluate autism symptom outcomes in a low and middle-income country setting. 40 parent-child dyads were recruited in a pilot randomized controlled trial against usual care (mean age 65 months (34 boys); n = 19 PASS Plus, n = 21 UC). 89% of intervention families partially or entirely completed the 12-session intervention. Intention to treat analysis showed a reduction in mean scores of autism symptom severity, though the confidence interval contains zero, (adjusted mean difference AMD -2.42 95% CI -7.75, 2.92; ES 0.22); large treatment effects on proximal outcomes of proportion of parent synchronous responses (AMD 0.35; 95% CI 0.18, 0.52; effect size ES 3.97) and proportion of child communication initiations with parent (AMD 0·17; 95% CI 0.03, 0.32; ES 1.02). Confidence intervals for effects on mutual shared attention (AMD 0.10; 95% CI -0.07, 0.27; ES 0.5) and co-morbid symptoms (AMD -9.0; 95% CI -24.26, 6.26; ES 0.32) contained zero. There were significant effects to improve parental mental health. PASS Plus shows good feasibility and adds to the evidence of the effectiveness of task sharing complex autism interventions to lay health workers in India.",
author = "Gauri Divan and Vivek Vajaratkar and Percy Cardozo and S Huzurbazar and M Verma and Elizabeth Howarth and Richard Emsley and Carol Taylor and Vikram Patel and Jonathan Green",
year = "2019",
month = feb,
day = "1",
doi = "10.1002/aur.1978",
language = "English",
journal = "Autism research : official journal of the International Society for Autism Research",
issn = "1939-3806",
publisher = "John Wiley & Sons Ltd",

}

RIS

TY - JOUR

T1 - The Feasibility and Effectiveness of PASS Plus, A Lay Health Worker Delivered Comprehensive Intervention for Autism Spectrum Disorders: Pilot RCT in a Rural Low and Middle Income Country Setting

AU - Divan, Gauri

AU - Vajaratkar, Vivek

AU - Cardozo, Percy

AU - Huzurbazar, S

AU - Verma, M

AU - Howarth, Elizabeth

AU - Emsley, Richard

AU - Taylor, Carol

AU - Patel, Vikram

AU - Green, Jonathan

PY - 2019/2/1

Y1 - 2019/2/1

N2 - The treatment gap for autism globally is high. Our previous PASS intervention, delivered by community based lay health workers, showed effectiveness. This article reports the development and evaluation of a new "PASS 'Plus'" intervention in a rural population in India. Using formative research methods, we supplemented the PASS intervention with additional (Plus) modules to address autism comorbidities. This is the first time that a rigorous methodology has been used to evaluate autism symptom outcomes in a low and middle-income country setting. 40 parent-child dyads were recruited in a pilot randomized controlled trial against usual care (mean age 65 months (34 boys); n = 19 PASS Plus, n = 21 UC). 89% of intervention families partially or entirely completed the 12-session intervention. Intention to treat analysis showed a reduction in mean scores of autism symptom severity, though the confidence interval contains zero, (adjusted mean difference AMD -2.42 95% CI -7.75, 2.92; ES 0.22); large treatment effects on proximal outcomes of proportion of parent synchronous responses (AMD 0.35; 95% CI 0.18, 0.52; effect size ES 3.97) and proportion of child communication initiations with parent (AMD 0·17; 95% CI 0.03, 0.32; ES 1.02). Confidence intervals for effects on mutual shared attention (AMD 0.10; 95% CI -0.07, 0.27; ES 0.5) and co-morbid symptoms (AMD -9.0; 95% CI -24.26, 6.26; ES 0.32) contained zero. There were significant effects to improve parental mental health. PASS Plus shows good feasibility and adds to the evidence of the effectiveness of task sharing complex autism interventions to lay health workers in India.

AB - The treatment gap for autism globally is high. Our previous PASS intervention, delivered by community based lay health workers, showed effectiveness. This article reports the development and evaluation of a new "PASS 'Plus'" intervention in a rural population in India. Using formative research methods, we supplemented the PASS intervention with additional (Plus) modules to address autism comorbidities. This is the first time that a rigorous methodology has been used to evaluate autism symptom outcomes in a low and middle-income country setting. 40 parent-child dyads were recruited in a pilot randomized controlled trial against usual care (mean age 65 months (34 boys); n = 19 PASS Plus, n = 21 UC). 89% of intervention families partially or entirely completed the 12-session intervention. Intention to treat analysis showed a reduction in mean scores of autism symptom severity, though the confidence interval contains zero, (adjusted mean difference AMD -2.42 95% CI -7.75, 2.92; ES 0.22); large treatment effects on proximal outcomes of proportion of parent synchronous responses (AMD 0.35; 95% CI 0.18, 0.52; effect size ES 3.97) and proportion of child communication initiations with parent (AMD 0·17; 95% CI 0.03, 0.32; ES 1.02). Confidence intervals for effects on mutual shared attention (AMD 0.10; 95% CI -0.07, 0.27; ES 0.5) and co-morbid symptoms (AMD -9.0; 95% CI -24.26, 6.26; ES 0.32) contained zero. There were significant effects to improve parental mental health. PASS Plus shows good feasibility and adds to the evidence of the effectiveness of task sharing complex autism interventions to lay health workers in India.

U2 - 10.1002/aur.1978

DO - 10.1002/aur.1978

M3 - Article

JO - Autism research : official journal of the International Society for Autism Research

JF - Autism research : official journal of the International Society for Autism Research

SN - 1939-3806

ER -