The effect of reducing the fine-particle mass of salmeterol from metered-dose inhalers on bronchodilatation and bronchoprotection against methacholine challenge: A randomized, placebo-controlled, double-blind, crossover study

Research output: Contribution to journalArticle

  • Authors:
  • David Allen
  • Barbara McDonnell
  • Neil Wheeler
  • Raj K. Sharma
  • Andrew Sykes
  • And 1 others
  • External authors:
  • Ashley Woodcock


Objective: This study examined the clinical relevance of fine-particle mass (FPM) delivered from metered dose inhalers (MDIs) to bronchodilatation and bronchoprotection against methacholine challenge by comparing a marketed chlorofluorocarbon (CFC) formulation of salmeterol with an investigational hydrofluoroalkane (HFA) formulation. Methods: This was a randomized, double-blind, placebo-controlled, 3-way crossover study in patients with mild to moderate asthma who had a forced expiratory volume in 1 second (FEV 1) of

Bibliographical metadata

Original languageEnglish
Pages (from-to)1004-1012
Number of pages8
JournalClinical Therapeutics
Issue number7
Publication statusPublished - Jul 2005