The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid MalignancyCitation formats

  • External authors:
  • Laura Mosteo
  • Joanna Storer
  • Delfim Duarte

Standard

The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy. / Mosteo, Laura ; Storer, Joanna; Batta, Kiran; Searle, Emma; Duarte, Delfim; Wiseman, Daniel.

In: Frontiers in cell and developmental biology, Vol. 9, 635189, 11.03.2021.

Research output: Contribution to journalReview articlepeer-review

Harvard

APA

Vancouver

Author

Mosteo, Laura ; Storer, Joanna ; Batta, Kiran ; Searle, Emma ; Duarte, Delfim ; Wiseman, Daniel. / The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy. In: Frontiers in cell and developmental biology. 2021 ; Vol. 9.

Bibtex

@article{21a499b8978847bf806658ddb0c9d982,
title = "The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy",
abstract = "Hematopoietic stem cells interact with bone marrow niches, including highly specialized blood vessels. Recent studies have revealed the phenotypic and functional heterogeneity of bone marrow endothelial cells. This has facilitated the analysis of the vascular microenvironment in steady state and malignant hematopoiesis. In this review, we provide an overview of the bone marrow microenvironment, focusing on refined analyses of the marrow vascular compartment performed in mouse studies. We also discuss the emerging role of the vascular niche in “inflamm-aging” and clonal hematopoiesis, and how the endothelial microenvironment influences, supports and interacts with hematopoietic cells in acute myeloid leukemia and myelodysplastic syndromes, as exemplar states of malignant myelopoiesis. Finally, we provide an overview of strategies for modulating these bidirectional interactions to therapeutic effect in myeloid malignancies.",
keywords = "acute myeloid leukemia, hematopoietic stem cells, myelodysplastic syndromes, targeted therapies, vascular niche",
author = "Laura Mosteo and Joanna Storer and Kiran Batta and Emma Searle and Delfim Duarte and Daniel Wiseman",
note = "Funding Information: Funding. DW and KB are supported by the Oglesby Charitable Trust. DW is additionally supported by a Blood Cancer United Kingdom Clinician Scientist Fellowship (number 15030). LM is supported by a grant from the National Blood Foundation (NBF). JS is supported by a Manchester Cancer Research Centre Studentship. ES is supported by research funding from The Christie Charitable Trust and The Academy of Medical Sciences. DD is funded by NBF, the European Hematology Association (EHA), and Funda??o Am?lia de Mello. Funding Information: DW and KB are supported by the Oglesby Charitable Trust. DW is additionally supported by a Blood Cancer United Kingdom Clinician Scientist Fellowship (number 15030). LM is supported by a grant from the National Blood Foundation (NBF). JS is supported by a Manchester Cancer Research Centre Studentship. ES is supported by research funding from The Christie Charitable Trust and The Academy of Medical Sciences. DD is funded by NBF, the European Hematology Association (EHA), and Funda{\c c}{\~a}o Am{\'e}lia de Mello. Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2021 Mosteo, Storer, Batta, Searle, Duarte and Wiseman.",
year = "2021",
month = mar,
day = "11",
doi = "10.3389/fcell.2021.635189",
language = "English",
volume = "9",
journal = "Frontiers in cell and developmental biology",
issn = "2296-6342",
publisher = "Frontiers Media S. A.",

}

RIS

TY - JOUR

T1 - The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy

AU - Mosteo, Laura

AU - Storer, Joanna

AU - Batta, Kiran

AU - Searle, Emma

AU - Duarte, Delfim

AU - Wiseman, Daniel

N1 - Funding Information: Funding. DW and KB are supported by the Oglesby Charitable Trust. DW is additionally supported by a Blood Cancer United Kingdom Clinician Scientist Fellowship (number 15030). LM is supported by a grant from the National Blood Foundation (NBF). JS is supported by a Manchester Cancer Research Centre Studentship. ES is supported by research funding from The Christie Charitable Trust and The Academy of Medical Sciences. DD is funded by NBF, the European Hematology Association (EHA), and Funda??o Am?lia de Mello. Funding Information: DW and KB are supported by the Oglesby Charitable Trust. DW is additionally supported by a Blood Cancer United Kingdom Clinician Scientist Fellowship (number 15030). LM is supported by a grant from the National Blood Foundation (NBF). JS is supported by a Manchester Cancer Research Centre Studentship. ES is supported by research funding from The Christie Charitable Trust and The Academy of Medical Sciences. DD is funded by NBF, the European Hematology Association (EHA), and Fundação Amélia de Mello. Publisher Copyright: © Copyright © 2021 Mosteo, Storer, Batta, Searle, Duarte and Wiseman.

PY - 2021/3/11

Y1 - 2021/3/11

N2 - Hematopoietic stem cells interact with bone marrow niches, including highly specialized blood vessels. Recent studies have revealed the phenotypic and functional heterogeneity of bone marrow endothelial cells. This has facilitated the analysis of the vascular microenvironment in steady state and malignant hematopoiesis. In this review, we provide an overview of the bone marrow microenvironment, focusing on refined analyses of the marrow vascular compartment performed in mouse studies. We also discuss the emerging role of the vascular niche in “inflamm-aging” and clonal hematopoiesis, and how the endothelial microenvironment influences, supports and interacts with hematopoietic cells in acute myeloid leukemia and myelodysplastic syndromes, as exemplar states of malignant myelopoiesis. Finally, we provide an overview of strategies for modulating these bidirectional interactions to therapeutic effect in myeloid malignancies.

AB - Hematopoietic stem cells interact with bone marrow niches, including highly specialized blood vessels. Recent studies have revealed the phenotypic and functional heterogeneity of bone marrow endothelial cells. This has facilitated the analysis of the vascular microenvironment in steady state and malignant hematopoiesis. In this review, we provide an overview of the bone marrow microenvironment, focusing on refined analyses of the marrow vascular compartment performed in mouse studies. We also discuss the emerging role of the vascular niche in “inflamm-aging” and clonal hematopoiesis, and how the endothelial microenvironment influences, supports and interacts with hematopoietic cells in acute myeloid leukemia and myelodysplastic syndromes, as exemplar states of malignant myelopoiesis. Finally, we provide an overview of strategies for modulating these bidirectional interactions to therapeutic effect in myeloid malignancies.

KW - acute myeloid leukemia

KW - hematopoietic stem cells

KW - myelodysplastic syndromes

KW - targeted therapies

KW - vascular niche

U2 - 10.3389/fcell.2021.635189

DO - 10.3389/fcell.2021.635189

M3 - Review article

C2 - 33777944

VL - 9

JO - Frontiers in cell and developmental biology

JF - Frontiers in cell and developmental biology

SN - 2296-6342

M1 - 635189

ER -