The Control of Diastolic Calcium in the HeartCitation formats

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The Control of Diastolic Calcium in the Heart : Basic Mechanisms and Functional Implications. / Eisner, David; Trafford, Andrew; Caldwell, Jessica; Hutchings, David.

In: Circulation research, Vol. 126, No. 3, 31.01.2020.

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@article{2717f3a344734767999a2658fbf3172c,
title = "The Control of Diastolic Calcium in the Heart: Basic Mechanisms and Functional Implications",
abstract = "Normal cardiac function requires that intracellular Ca2+ concentration ([Ca2+]i) be reduced to low levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often associated with impaired cardiac relaxation. Little, however, is known about how diastolic [Ca2+]i is regulated. This article first discusses the reasons for this ignorance before reviewing the basic mechanisms that control diastolic [Ca2+]i. It then considers how the control of systolic and diastolic [Ca2+]i are intimately connected. Finally, it discusses the changes that occur in heart failure and how these may result in heart failure with preserved versus reduced ejection fraction. ",
keywords = "calcium, diastole, heart failure, HFpEF, HFrEF",
author = "David Eisner and Andrew Trafford and Jessica Caldwell and David Hutchings",
year = "2020",
month = jan,
day = "31",
doi = "10.1161/CIRCRESAHA.119.315891",
language = "English",
volume = "126",
journal = "Circulation research",
issn = "0009-7330",
publisher = "Lippincott Williams & Wilkins",
number = "3",

}

RIS

TY - JOUR

T1 - The Control of Diastolic Calcium in the Heart

T2 - Basic Mechanisms and Functional Implications

AU - Eisner, David

AU - Trafford, Andrew

AU - Caldwell, Jessica

AU - Hutchings, David

PY - 2020/1/31

Y1 - 2020/1/31

N2 - Normal cardiac function requires that intracellular Ca2+ concentration ([Ca2+]i) be reduced to low levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often associated with impaired cardiac relaxation. Little, however, is known about how diastolic [Ca2+]i is regulated. This article first discusses the reasons for this ignorance before reviewing the basic mechanisms that control diastolic [Ca2+]i. It then considers how the control of systolic and diastolic [Ca2+]i are intimately connected. Finally, it discusses the changes that occur in heart failure and how these may result in heart failure with preserved versus reduced ejection fraction.

AB - Normal cardiac function requires that intracellular Ca2+ concentration ([Ca2+]i) be reduced to low levels in diastole so that the ventricle can relax and refill with blood. Heart failure is often associated with impaired cardiac relaxation. Little, however, is known about how diastolic [Ca2+]i is regulated. This article first discusses the reasons for this ignorance before reviewing the basic mechanisms that control diastolic [Ca2+]i. It then considers how the control of systolic and diastolic [Ca2+]i are intimately connected. Finally, it discusses the changes that occur in heart failure and how these may result in heart failure with preserved versus reduced ejection fraction.

KW - calcium

KW - diastole

KW - heart failure

KW - HFpEF

KW - HFrEF

U2 - 10.1161/CIRCRESAHA.119.315891

DO - 10.1161/CIRCRESAHA.119.315891

M3 - Article

VL - 126

JO - Circulation research

JF - Circulation research

SN - 0009-7330

IS - 3

ER -