The alchemy of immune privilege explored from a neuroimmunological perspectiveCitation formats

  • Authors:
  • Petra Clara Arck
  • Amos Gilhar
  • John Bienenstock
  • Ralf Paus

Standard

The alchemy of immune privilege explored from a neuroimmunological perspective. / Arck, Petra Clara; Gilhar, Amos; Bienenstock, John; Paus, Ralf.

In: Current opinion in pharmacology, Vol. 8, No. 4, 08.2008, p. 480-489.

Research output: Contribution to journalArticle

Harvard

Arck, PC, Gilhar, A, Bienenstock, J & Paus, R 2008, 'The alchemy of immune privilege explored from a neuroimmunological perspective', Current opinion in pharmacology, vol. 8, no. 4, pp. 480-489. https://doi.org/10.1016/j.coph.2008.06.003

APA

Arck, P. C., Gilhar, A., Bienenstock, J., & Paus, R. (2008). The alchemy of immune privilege explored from a neuroimmunological perspective. Current opinion in pharmacology, 8(4), 480-489. https://doi.org/10.1016/j.coph.2008.06.003

Vancouver

Arck PC, Gilhar A, Bienenstock J, Paus R. The alchemy of immune privilege explored from a neuroimmunological perspective. Current opinion in pharmacology. 2008 Aug;8(4):480-489. https://doi.org/10.1016/j.coph.2008.06.003

Author

Arck, Petra Clara ; Gilhar, Amos ; Bienenstock, John ; Paus, Ralf. / The alchemy of immune privilege explored from a neuroimmunological perspective. In: Current opinion in pharmacology. 2008 ; Vol. 8, No. 4. pp. 480-489.

Bibtex

@article{fc3132c1f53b43b8b853cf22c8125471,
title = "The alchemy of immune privilege explored from a neuroimmunological perspective",
abstract = "The term 'immune privilege' (IP) generally describes the protection of vital structures, such as the brain, the eye, or the pregnant uterus, from the potentially damaging effects of an inflammatory immune response. Initially, barriers physically camouflaging such organs were thought to shield autoantigens from immune recognition and inflammation. This simplistic concept gave way to a much more complex understanding of IP, which reflects an entire network of interacting immunoregulatory processes and immunosuppressive microenvironments. Also, the number of organs and tissues that enjoy relative IP has grown considerably. This is not surprising since many different organs are constantly exposed to major, potentially damaging inflammatory events, for example, skin, gut, or lung-without evidence for excessive inflammation under physiological conditions. Focusing on fetotrophoblast IP as well as on hair-follicle-associated IP (an underappreciated, yet biologically fascinating, clinically important IP model), we summarize here key regulatory cues that operate in immunoprivileged tissues. Proposing novel concepts of how IP may collapse, for example, by exposure to psychosocial, stress-associated inflammation, we develop related strategies for how IP may be manipulated clinically so as to achieve IP protection and restoration. {\circledC} 2008 Elsevier Ltd. All rights reserved.",
keywords = "Animals, Humans, physiology: Immune System, immunology: Nervous System Physiological Phenomena, immunology: Stress, Psychological",
author = "Arck, {Petra Clara} and Amos Gilhar and John Bienenstock and Ralf Paus",
year = "2008",
month = "8",
doi = "10.1016/j.coph.2008.06.003",
language = "English",
volume = "8",
pages = "480--489",
journal = "Current opinion in pharmacology",
issn = "1471-4892",
publisher = "Elsevier BV",
number = "4",

}

RIS

TY - JOUR

T1 - The alchemy of immune privilege explored from a neuroimmunological perspective

AU - Arck, Petra Clara

AU - Gilhar, Amos

AU - Bienenstock, John

AU - Paus, Ralf

PY - 2008/8

Y1 - 2008/8

N2 - The term 'immune privilege' (IP) generally describes the protection of vital structures, such as the brain, the eye, or the pregnant uterus, from the potentially damaging effects of an inflammatory immune response. Initially, barriers physically camouflaging such organs were thought to shield autoantigens from immune recognition and inflammation. This simplistic concept gave way to a much more complex understanding of IP, which reflects an entire network of interacting immunoregulatory processes and immunosuppressive microenvironments. Also, the number of organs and tissues that enjoy relative IP has grown considerably. This is not surprising since many different organs are constantly exposed to major, potentially damaging inflammatory events, for example, skin, gut, or lung-without evidence for excessive inflammation under physiological conditions. Focusing on fetotrophoblast IP as well as on hair-follicle-associated IP (an underappreciated, yet biologically fascinating, clinically important IP model), we summarize here key regulatory cues that operate in immunoprivileged tissues. Proposing novel concepts of how IP may collapse, for example, by exposure to psychosocial, stress-associated inflammation, we develop related strategies for how IP may be manipulated clinically so as to achieve IP protection and restoration. © 2008 Elsevier Ltd. All rights reserved.

AB - The term 'immune privilege' (IP) generally describes the protection of vital structures, such as the brain, the eye, or the pregnant uterus, from the potentially damaging effects of an inflammatory immune response. Initially, barriers physically camouflaging such organs were thought to shield autoantigens from immune recognition and inflammation. This simplistic concept gave way to a much more complex understanding of IP, which reflects an entire network of interacting immunoregulatory processes and immunosuppressive microenvironments. Also, the number of organs and tissues that enjoy relative IP has grown considerably. This is not surprising since many different organs are constantly exposed to major, potentially damaging inflammatory events, for example, skin, gut, or lung-without evidence for excessive inflammation under physiological conditions. Focusing on fetotrophoblast IP as well as on hair-follicle-associated IP (an underappreciated, yet biologically fascinating, clinically important IP model), we summarize here key regulatory cues that operate in immunoprivileged tissues. Proposing novel concepts of how IP may collapse, for example, by exposure to psychosocial, stress-associated inflammation, we develop related strategies for how IP may be manipulated clinically so as to achieve IP protection and restoration. © 2008 Elsevier Ltd. All rights reserved.

KW - Animals

KW - Humans

KW - physiology: Immune System

KW - immunology: Nervous System Physiological Phenomena

KW - immunology: Stress, Psychological

U2 - 10.1016/j.coph.2008.06.003

DO - 10.1016/j.coph.2008.06.003

M3 - Article

VL - 8

SP - 480

EP - 489

JO - Current opinion in pharmacology

JF - Current opinion in pharmacology

SN - 1471-4892

IS - 4

ER -