The -403 G→A promoter polymorphism in the RANTES gene is associated with atopy and asthmaCitation formats

  • External authors:
  • A. A. Fryer
  • M. A. Spiteri
  • A. Bianco
  • M. Hepple
  • P. W. Jones
  • R. C. Strange
  • R. Makki
  • G. Tavernier
  • F. I. Smilie
  • A. Custovic
  • A. A. Woodcock
  • A. H. Hajeer

Standard

The -403 G→A promoter polymorphism in the RANTES gene is associated with atopy and asthma. / Fryer, A. A.; Spiteri, M. A.; Bianco, A.; Hepple, M.; Jones, P. W.; Strange, R. C.; Makki, R.; Tavernier, G.; Smilie, F. I.; Custovic, A.; Woodcock, A. A.; Ollier, W. E R; Hajeer, A. H.

In: Genes and Immunity, Vol. 1, No. 8, 12.2000, p. 509-514.

Research output: Contribution to journalArticle

Harvard

Fryer, AA, Spiteri, MA, Bianco, A, Hepple, M, Jones, PW, Strange, RC, Makki, R, Tavernier, G, Smilie, FI, Custovic, A, Woodcock, AA, Ollier, WER & Hajeer, AH 2000, 'The -403 G→A promoter polymorphism in the RANTES gene is associated with atopy and asthma' Genes and Immunity, vol. 1, no. 8, pp. 509-514. https://doi.org/10.1038/sj.gene.6363717

APA

Fryer, A. A., Spiteri, M. A., Bianco, A., Hepple, M., Jones, P. W., Strange, R. C., ... Hajeer, A. H. (2000). The -403 G→A promoter polymorphism in the RANTES gene is associated with atopy and asthma. Genes and Immunity, 1(8), 509-514. https://doi.org/10.1038/sj.gene.6363717

Vancouver

Fryer AA, Spiteri MA, Bianco A, Hepple M, Jones PW, Strange RC et al. The -403 G→A promoter polymorphism in the RANTES gene is associated with atopy and asthma. Genes and Immunity. 2000 Dec;1(8):509-514. https://doi.org/10.1038/sj.gene.6363717

Author

Fryer, A. A. ; Spiteri, M. A. ; Bianco, A. ; Hepple, M. ; Jones, P. W. ; Strange, R. C. ; Makki, R. ; Tavernier, G. ; Smilie, F. I. ; Custovic, A. ; Woodcock, A. A. ; Ollier, W. E R ; Hajeer, A. H. / The -403 G→A promoter polymorphism in the RANTES gene is associated with atopy and asthma. In: Genes and Immunity. 2000 ; Vol. 1, No. 8. pp. 509-514.

Bibtex

@article{d5237b46e51f4a07bd6475af75506748,
title = "The -403 G→A promoter polymorphism in the RANTES gene is associated with atopy and asthma",
abstract = "Asthma is a complex inflammatory condition often associated with bronchial hyperreactivity and atopy. Genetic and environmental factors are implicated and several candidate genes have been implicated. Of these, the chemokine RANTES is responsible for the recruitment of inflammatory cells such as eosinophils and T-lymphocytes. We have recently identified a polymorphism within the RANTES promoter (-403 G-→A) and have examined its role, using a PCR-RFLP assay, in the development of atopy and asthma in 201 Caucasian subjects. Atopic status was determined using skin prick testing and serum IgE levels. Severity of airway dysfunction was assessed using spirometric measurement (FEV1) and methacholine challenge (PC20). The -403 A allele was associated with an increased susceptibility to both atopy and asthma. Thus, the proportion of subjects carrying this allele was higher in each of atopic non-asthmatics, non-atopic asthmatics and atopic asthmatics compared with non-atopic, non-asthmatic controls. In particular, this allele was associated with skin test positivity but not IgE level. Homozygosity for the -403 A allele conferred a 6.5-fold increased risk of moderate/severe airway obstruction (FEV1 ≤80{\%} predicted), a marker for established asthma. Our data, whilst preliminary, indicate that the association of RANTES genotype with both atopy and asthma reflect independent effects, suggesting different mechanisms for the role of this chemokine in atopy and development of airway obstruction.",
keywords = "Asthma, Atopy, Polymorphism, RANTES",
author = "Fryer, {A. A.} and Spiteri, {M. A.} and A. Bianco and M. Hepple and Jones, {P. W.} and Strange, {R. C.} and R. Makki and G. Tavernier and Smilie, {F. I.} and A. Custovic and Woodcock, {A. A.} and Ollier, {W. E R} and Hajeer, {A. H.}",
year = "2000",
month = "12",
doi = "10.1038/sj.gene.6363717",
language = "English",
volume = "1",
pages = "509--514",
journal = "Genes and Immunity",
issn = "1466-4879",
publisher = "Springer Nature",
number = "8",

}

RIS

TY - JOUR

T1 - The -403 G→A promoter polymorphism in the RANTES gene is associated with atopy and asthma

AU - Fryer, A. A.

AU - Spiteri, M. A.

AU - Bianco, A.

AU - Hepple, M.

AU - Jones, P. W.

AU - Strange, R. C.

AU - Makki, R.

AU - Tavernier, G.

AU - Smilie, F. I.

AU - Custovic, A.

AU - Woodcock, A. A.

AU - Ollier, W. E R

AU - Hajeer, A. H.

PY - 2000/12

Y1 - 2000/12

N2 - Asthma is a complex inflammatory condition often associated with bronchial hyperreactivity and atopy. Genetic and environmental factors are implicated and several candidate genes have been implicated. Of these, the chemokine RANTES is responsible for the recruitment of inflammatory cells such as eosinophils and T-lymphocytes. We have recently identified a polymorphism within the RANTES promoter (-403 G-→A) and have examined its role, using a PCR-RFLP assay, in the development of atopy and asthma in 201 Caucasian subjects. Atopic status was determined using skin prick testing and serum IgE levels. Severity of airway dysfunction was assessed using spirometric measurement (FEV1) and methacholine challenge (PC20). The -403 A allele was associated with an increased susceptibility to both atopy and asthma. Thus, the proportion of subjects carrying this allele was higher in each of atopic non-asthmatics, non-atopic asthmatics and atopic asthmatics compared with non-atopic, non-asthmatic controls. In particular, this allele was associated with skin test positivity but not IgE level. Homozygosity for the -403 A allele conferred a 6.5-fold increased risk of moderate/severe airway obstruction (FEV1 ≤80% predicted), a marker for established asthma. Our data, whilst preliminary, indicate that the association of RANTES genotype with both atopy and asthma reflect independent effects, suggesting different mechanisms for the role of this chemokine in atopy and development of airway obstruction.

AB - Asthma is a complex inflammatory condition often associated with bronchial hyperreactivity and atopy. Genetic and environmental factors are implicated and several candidate genes have been implicated. Of these, the chemokine RANTES is responsible for the recruitment of inflammatory cells such as eosinophils and T-lymphocytes. We have recently identified a polymorphism within the RANTES promoter (-403 G-→A) and have examined its role, using a PCR-RFLP assay, in the development of atopy and asthma in 201 Caucasian subjects. Atopic status was determined using skin prick testing and serum IgE levels. Severity of airway dysfunction was assessed using spirometric measurement (FEV1) and methacholine challenge (PC20). The -403 A allele was associated with an increased susceptibility to both atopy and asthma. Thus, the proportion of subjects carrying this allele was higher in each of atopic non-asthmatics, non-atopic asthmatics and atopic asthmatics compared with non-atopic, non-asthmatic controls. In particular, this allele was associated with skin test positivity but not IgE level. Homozygosity for the -403 A allele conferred a 6.5-fold increased risk of moderate/severe airway obstruction (FEV1 ≤80% predicted), a marker for established asthma. Our data, whilst preliminary, indicate that the association of RANTES genotype with both atopy and asthma reflect independent effects, suggesting different mechanisms for the role of this chemokine in atopy and development of airway obstruction.

KW - Asthma

KW - Atopy

KW - Polymorphism

KW - RANTES

U2 - 10.1038/sj.gene.6363717

DO - 10.1038/sj.gene.6363717

M3 - Article

VL - 1

SP - 509

EP - 514

JO - Genes and Immunity

JF - Genes and Immunity

SN - 1466-4879

IS - 8

ER -