Synthetic heparan sulfate dodecasaccharides reveal single sulfation site interconverts CXCL8 and CXCL12 chemokine biology

Research output: Contribution to journalArticle

  • External authors:
  • Steen U Hansen
  • Gavin J Miller
  • Claire L Cole
  • Graham Rushton

Abstract

The multigram-scale synthesis of a sulfation-site programmed heparin-like dodecasaccharide is described. Evaluation alongside dodecasaccharides lacking this single glucosamine O6-sulfation, or having per-O6-sulfation, shows that site-specific modification of the terminal glucosamine dramatically interconverts regulation of in vitro and in vivo biology mediated by the two important chemokines, CXCL12 (SDF1α) or CXCL8 (IL-8).

Bibliographical metadata

Original languageEnglish
Pages (from-to)13846-9
Number of pages4
JournalChemical Communications
Volume51
Issue number72
DOIs
StatePublished - 18 Sep 2015