Synthesis of Hybrid Natural Product Analogues with Anti-tumour Properties

Research output: Contribution to journalArticle

  • External authors:
  • Stephania Christou
  • Alyn Edwards
  • Robin Pritchard
  • Yiwei Song
  • Katharine Williams
  • Roger Whitehead

Abstract

High yielding and diastereoselective conjugate addition reactions of a (-)-quinic acid derived enone have provided access to a small library of hybrid analogues of the anti-tumour natural products antheminone A and COTC. The novel compounds were assessed for their antiproliferative activities towards the A549 non-small-cell lung cancer cell line revealing some useful structure-activity relationships.

Bibliographical metadata

Original languageEnglish
Pages (from-to) 5433–5443
JournalTetrahedron
Volume72
Issue number35
Early online date11 Jul 2016
DOIs
StatePublished - 1 Sep 2016