Synthesis and Characterization of Mesoporous Mg- and Sr-Doped Nanoparticles for Moxifloxacin Drug Delivery in Promising Tissue Engineering ApplicationsCitation formats

  • External authors:
  • Georgia K. Pouroutzidou
  • Liliana Liverani
  • Anna Theocharidou
  • Ioannis Tsamesidis
  • Maria Lazaridou
  • Evi Christodoulou
  • Anastasia Beketova
  • Christina Pappa
  • Konstantinos S. Triantafyllidis
  • Lambrini Papadopoulou
  • Dimitrios N. Bikiaris
  • Aldo R. Boccaccini
  • Eleana Kontonasaki

Standard

Synthesis and Characterization of Mesoporous Mg- and Sr-Doped Nanoparticles for Moxifloxacin Drug Delivery in Promising Tissue Engineering Applications. / Pouroutzidou, Georgia K.; Liverani, Liliana; Theocharidou, Anna; Tsamesidis, Ioannis; Lazaridou, Maria; Christodoulou, Evi; Beketova, Anastasia; Pappa, Christina; Triantafyllidis, Konstantinos S.; Anastasiou, Antonios D.; Papadopoulou, Lambrini; Bikiaris, Dimitrios N.; Boccaccini, Aldo R.; Kontonasaki, Eleana.

In: International Journal of Molecular Sciences, Vol. 22, No. 2, 577, 08.01.2021, p. 1-25.

Research output: Contribution to journalArticlepeer-review

Harvard

Pouroutzidou, GK, Liverani, L, Theocharidou, A, Tsamesidis, I, Lazaridou, M, Christodoulou, E, Beketova, A, Pappa, C, Triantafyllidis, KS, Anastasiou, AD, Papadopoulou, L, Bikiaris, DN, Boccaccini, AR & Kontonasaki, E 2021, 'Synthesis and Characterization of Mesoporous Mg- and Sr-Doped Nanoparticles for Moxifloxacin Drug Delivery in Promising Tissue Engineering Applications', International Journal of Molecular Sciences, vol. 22, no. 2, 577, pp. 1-25. https://doi.org/10.3390/ijms22020577

APA

Pouroutzidou, G. K., Liverani, L., Theocharidou, A., Tsamesidis, I., Lazaridou, M., Christodoulou, E., Beketova, A., Pappa, C., Triantafyllidis, K. S., Anastasiou, A. D., Papadopoulou, L., Bikiaris, D. N., Boccaccini, A. R., & Kontonasaki, E. (2021). Synthesis and Characterization of Mesoporous Mg- and Sr-Doped Nanoparticles for Moxifloxacin Drug Delivery in Promising Tissue Engineering Applications. International Journal of Molecular Sciences, 22(2), 1-25. [577]. https://doi.org/10.3390/ijms22020577

Vancouver

Pouroutzidou GK, Liverani L, Theocharidou A, Tsamesidis I, Lazaridou M, Christodoulou E et al. Synthesis and Characterization of Mesoporous Mg- and Sr-Doped Nanoparticles for Moxifloxacin Drug Delivery in Promising Tissue Engineering Applications. International Journal of Molecular Sciences. 2021 Jan 8;22(2):1-25. 577. https://doi.org/10.3390/ijms22020577

Author

Pouroutzidou, Georgia K. ; Liverani, Liliana ; Theocharidou, Anna ; Tsamesidis, Ioannis ; Lazaridou, Maria ; Christodoulou, Evi ; Beketova, Anastasia ; Pappa, Christina ; Triantafyllidis, Konstantinos S. ; Anastasiou, Antonios D. ; Papadopoulou, Lambrini ; Bikiaris, Dimitrios N. ; Boccaccini, Aldo R. ; Kontonasaki, Eleana. / Synthesis and Characterization of Mesoporous Mg- and Sr-Doped Nanoparticles for Moxifloxacin Drug Delivery in Promising Tissue Engineering Applications. In: International Journal of Molecular Sciences. 2021 ; Vol. 22, No. 2. pp. 1-25.

Bibtex

@article{ef9fd5c46409472ea3fd3266e271d944,
title = "Synthesis and Characterization of Mesoporous Mg- and Sr-Doped Nanoparticles for Moxifloxacin Drug Delivery in Promising Tissue Engineering Applications",
abstract = "Mesoporous silica-based nanoparticles (MSNs) are considered promising drug carriers because of their ordered pore structure, which permits high drug loading and release capacity. The dissolution of Si and Ca from MSNs can trigger osteogenic differentiation of stem cells towards extracellular matrix calcification, while Mg and Sr constitute key elements of bone biology and metabolism. The aim of this study was the synthesis and characterization of sol–gel-derived MSNs codoped with Ca, Mg and Sr. Their physico-chemical properties were investigated by X-ray diffraction (XRD), scanning electron microscopy with energy dispersive X-ray analysis (SEM/EDX), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), X-ray fluorescence spectroscopy (XRF), Brunauer Emmett Teller and Brunauer Joyner Halenda (BET/BJH), dynamic light scattering (DLS) and ζ-potential measurements. Moxifloxacin loading and release profiles were assessed with high performance liquid chromatography (HPLC) cell viability on human periodontal ligament fibroblasts and their hemolytic activity in contact with human red blood cells (RBCs) at various concentrations were also investigated. Doped MSNs generally retained their textural characteristics, while different compositions affected particle size, hemolytic activity and moxifloxacin loading/release profiles. All co-doped MSNs revealed the formation of hydroxycarbonate apatite on their surface after immersion in simulated body fluid (SBF) and promoted mitochondrial activity and cell proliferation.",
keywords = "Drug loading/release, Human erythrocytes, Mesoporous nanoparticles, Moxifloxacin, Periodontal ligament cells",
author = "Pouroutzidou, {Georgia K.} and Liliana Liverani and Anna Theocharidou and Ioannis Tsamesidis and Maria Lazaridou and Evi Christodoulou and Anastasia Beketova and Christina Pappa and Triantafyllidis, {Konstantinos S.} and Anastasiou, {Antonios D.} and Lambrini Papadopoulou and Bikiaris, {Dimitrios N.} and Boccaccini, {Aldo R.} and Eleana Kontonasaki",
note = "Funding Information: Funding: A part of this research is co-financed by Greece and the European Union (European Social Fund-ESF) through the Operational Programme «Human Resources Development, Education and Lifelong Learning» in the context of the project “Strengthening Human Resources Research Potential via Doctorate Research” (MIS-5000432), implemented by the State Scholarships Foundation (IKΥ). Part of this research received funding by DAAD, Germany (DAAD Programme des Projektbezogenen Personenaustauschs with Greece (DAAD-PPP), project number 57418507), in the frame of Greek-German collaboration (IKYDA 2018–2020). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = jan,
day = "8",
doi = "10.3390/ijms22020577",
language = "English",
volume = "22",
pages = "1--25",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI",
number = "2",

}

RIS

TY - JOUR

T1 - Synthesis and Characterization of Mesoporous Mg- and Sr-Doped Nanoparticles for Moxifloxacin Drug Delivery in Promising Tissue Engineering Applications

AU - Pouroutzidou, Georgia K.

AU - Liverani, Liliana

AU - Theocharidou, Anna

AU - Tsamesidis, Ioannis

AU - Lazaridou, Maria

AU - Christodoulou, Evi

AU - Beketova, Anastasia

AU - Pappa, Christina

AU - Triantafyllidis, Konstantinos S.

AU - Anastasiou, Antonios D.

AU - Papadopoulou, Lambrini

AU - Bikiaris, Dimitrios N.

AU - Boccaccini, Aldo R.

AU - Kontonasaki, Eleana

N1 - Funding Information: Funding: A part of this research is co-financed by Greece and the European Union (European Social Fund-ESF) through the Operational Programme «Human Resources Development, Education and Lifelong Learning» in the context of the project “Strengthening Human Resources Research Potential via Doctorate Research” (MIS-5000432), implemented by the State Scholarships Foundation (IKΥ). Part of this research received funding by DAAD, Germany (DAAD Programme des Projektbezogenen Personenaustauschs with Greece (DAAD-PPP), project number 57418507), in the frame of Greek-German collaboration (IKYDA 2018–2020). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/1/8

Y1 - 2021/1/8

N2 - Mesoporous silica-based nanoparticles (MSNs) are considered promising drug carriers because of their ordered pore structure, which permits high drug loading and release capacity. The dissolution of Si and Ca from MSNs can trigger osteogenic differentiation of stem cells towards extracellular matrix calcification, while Mg and Sr constitute key elements of bone biology and metabolism. The aim of this study was the synthesis and characterization of sol–gel-derived MSNs codoped with Ca, Mg and Sr. Their physico-chemical properties were investigated by X-ray diffraction (XRD), scanning electron microscopy with energy dispersive X-ray analysis (SEM/EDX), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), X-ray fluorescence spectroscopy (XRF), Brunauer Emmett Teller and Brunauer Joyner Halenda (BET/BJH), dynamic light scattering (DLS) and ζ-potential measurements. Moxifloxacin loading and release profiles were assessed with high performance liquid chromatography (HPLC) cell viability on human periodontal ligament fibroblasts and their hemolytic activity in contact with human red blood cells (RBCs) at various concentrations were also investigated. Doped MSNs generally retained their textural characteristics, while different compositions affected particle size, hemolytic activity and moxifloxacin loading/release profiles. All co-doped MSNs revealed the formation of hydroxycarbonate apatite on their surface after immersion in simulated body fluid (SBF) and promoted mitochondrial activity and cell proliferation.

AB - Mesoporous silica-based nanoparticles (MSNs) are considered promising drug carriers because of their ordered pore structure, which permits high drug loading and release capacity. The dissolution of Si and Ca from MSNs can trigger osteogenic differentiation of stem cells towards extracellular matrix calcification, while Mg and Sr constitute key elements of bone biology and metabolism. The aim of this study was the synthesis and characterization of sol–gel-derived MSNs codoped with Ca, Mg and Sr. Their physico-chemical properties were investigated by X-ray diffraction (XRD), scanning electron microscopy with energy dispersive X-ray analysis (SEM/EDX), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), X-ray fluorescence spectroscopy (XRF), Brunauer Emmett Teller and Brunauer Joyner Halenda (BET/BJH), dynamic light scattering (DLS) and ζ-potential measurements. Moxifloxacin loading and release profiles were assessed with high performance liquid chromatography (HPLC) cell viability on human periodontal ligament fibroblasts and their hemolytic activity in contact with human red blood cells (RBCs) at various concentrations were also investigated. Doped MSNs generally retained their textural characteristics, while different compositions affected particle size, hemolytic activity and moxifloxacin loading/release profiles. All co-doped MSNs revealed the formation of hydroxycarbonate apatite on their surface after immersion in simulated body fluid (SBF) and promoted mitochondrial activity and cell proliferation.

KW - Drug loading/release

KW - Human erythrocytes

KW - Mesoporous nanoparticles

KW - Moxifloxacin

KW - Periodontal ligament cells

UR - http://www.scopus.com/inward/record.url?scp=85099132148&partnerID=8YFLogxK

U2 - 10.3390/ijms22020577

DO - 10.3390/ijms22020577

M3 - Article

C2 - 33430065

AN - SCOPUS:85099132148

VL - 22

SP - 1

EP - 25

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 2

M1 - 577

ER -