Synthesis and characterisation of fluorescent pyrene-end-capped polylactide fibres

Research output: Contribution to journalArticle

  • External authors:
  • Aula Alwattar
  • Athir Haddad
  • Quan Zhou
  • Tatiana Nascimento
  • Ryan Greenhalgh
  • Eliton Medeiros

Abstract

Fluorescent markers are critical for tracking the position and movement of molecules both in vivo and in vitro. Conventionally, synthetic dyes are non-covalently added to polymers for fluorescent tracking but often diffuse away. Here we demonstrate, for the first time, a facile method for the synthesis of fluorescent polylactic acid PLA nano/-microfibres for biomedical applications using solution spin blowing (SBS). Pyrene end capped poly(L-lactide) (PLLA) derivatives were synthesised using the ring opening polymerisation of L-lactide and their characterisation using spectroscopic and thermal analysis. Submicron-sized fluorescent fibres were produced from these PLLA derivatives using solution blow spinning techniques generating polymer blends and core-shell fibres. Such system could be further exploited to incorporate electrically conductive carbon allotropes via the pyrene aromaticity, producing fluorescent and electrically active fibres for in vitro monitoring and electrical stimulation.

Bibliographical metadata

Original languageEnglish
Pages (from-to)360-368
Number of pages9
JournalPolymer International
Volume68
Issue number3
Early online date28 Sep 2018
DOIs
Publication statusPublished - 1 Mar 2019