Synovial volume vs synovial measurements from dynamic contrast enhanced MRI as measures of response in osteoarthritisCitation formats

  • External authors:
  • Richard Hodgson
  • C Hutchinson
  • Nasimah Maricar
  • Elizabeth Marjanovic

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Synovial volume vs synovial measurements from dynamic contrast enhanced MRI as measures of response in osteoarthritis. / Gait, Andrew; Hodgson, Richard; Parkes, Matthew; Hutchinson, C; O'Neill, Terence; Maricar, Nasimah; Marjanovic, Elizabeth; Cootes, Timothy; Felson, David.

In: Osteoarthritis and Cartilage, Vol. 24, No. 8, 08.2016, p. 1392-1398.

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Gait, Andrew ; Hodgson, Richard ; Parkes, Matthew ; Hutchinson, C ; O'Neill, Terence ; Maricar, Nasimah ; Marjanovic, Elizabeth ; Cootes, Timothy ; Felson, David. / Synovial volume vs synovial measurements from dynamic contrast enhanced MRI as measures of response in osteoarthritis. In: Osteoarthritis and Cartilage. 2016 ; Vol. 24, No. 8. pp. 1392-1398.

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@article{64c4557aa0c9404d95ada040ff7ff52e,
title = "Synovial volume vs synovial measurements from dynamic contrast enhanced MRI as measures of response in osteoarthritis",
abstract = "ObjectiveSynovium is increasingly a target of osteoarthritis (OA) treatment, yet its optimal measurement is unclear. Using dynamic contrast enhanced (DCE) MRI in knee OA patients before and after intraarticular steroid injection, we compared the responsiveness of static synovial volume measures to measures of dynamic changes in synovial enhancement, changes that are strongly related to synovial vascularity.MethodsNinety three patients underwent DCE-MRI before and 1–2 weeks after intra-articular injection of 80 mg methylprednisolone. Synovium was segmented and volume, relative enhancement rate (RER), maximum relative enhancement (REmax), late relative enhancement (RElate) and pharmacokinetic parameters (Ktrans, ve) were calculated. KOOS (​knee injury and osteoarthritis outcome score) pain score was recorded before and after injection. Standardized change scores were calculated for each parameter. Linear regression and Pearson's correlations were used to investigate the relationship between change in MRI parameters and change in pain.ResultsThe change in standardized score for the measures of synovial enhancement, RElate and REmax were −0.58 (95% CI −0.79 to −0.37) and −0.62 (95% CI −0.83 to −0.41) respectively, whereas the score for synovial volume was −0.30 (−0.52 to −0.09). Further, change in knee pain correlated more strongly with changes in enhancement (for both REmax and RElate, r = −0.27 (95% CI −0.45 to −0.07)) than with changes in synovial volume −0.15 (−0.35 to 0.05).ConclusionThis study suggests DCE-MRI derived measures of synovial enhancement may be more sensitive to the response to treatment and more strongly associated with changes in pain than synovial volume and may be better outcomes for assessment of structural effects of treatment in OA.",
author = "Andrew Gait and Richard Hodgson and Matthew Parkes and C Hutchinson and Terence O'Neill and Nasimah Maricar and Elizabeth Marjanovic and Timothy Cootes and David Felson",
year = "2016",
month = aug
doi = "10.1016/j.joca.2016.03.015",
language = "English",
volume = "24",
pages = "1392--1398",
journal = "Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society",
issn = "1063-4584",
publisher = "W.B. Saunders Co. Ltd",
number = "8",

}

RIS

TY - JOUR

T1 - Synovial volume vs synovial measurements from dynamic contrast enhanced MRI as measures of response in osteoarthritis

AU - Gait, Andrew

AU - Hodgson, Richard

AU - Parkes, Matthew

AU - Hutchinson, C

AU - O'Neill, Terence

AU - Maricar, Nasimah

AU - Marjanovic, Elizabeth

AU - Cootes, Timothy

AU - Felson, David

PY - 2016/8

Y1 - 2016/8

N2 - ObjectiveSynovium is increasingly a target of osteoarthritis (OA) treatment, yet its optimal measurement is unclear. Using dynamic contrast enhanced (DCE) MRI in knee OA patients before and after intraarticular steroid injection, we compared the responsiveness of static synovial volume measures to measures of dynamic changes in synovial enhancement, changes that are strongly related to synovial vascularity.MethodsNinety three patients underwent DCE-MRI before and 1–2 weeks after intra-articular injection of 80 mg methylprednisolone. Synovium was segmented and volume, relative enhancement rate (RER), maximum relative enhancement (REmax), late relative enhancement (RElate) and pharmacokinetic parameters (Ktrans, ve) were calculated. KOOS (​knee injury and osteoarthritis outcome score) pain score was recorded before and after injection. Standardized change scores were calculated for each parameter. Linear regression and Pearson's correlations were used to investigate the relationship between change in MRI parameters and change in pain.ResultsThe change in standardized score for the measures of synovial enhancement, RElate and REmax were −0.58 (95% CI −0.79 to −0.37) and −0.62 (95% CI −0.83 to −0.41) respectively, whereas the score for synovial volume was −0.30 (−0.52 to −0.09). Further, change in knee pain correlated more strongly with changes in enhancement (for both REmax and RElate, r = −0.27 (95% CI −0.45 to −0.07)) than with changes in synovial volume −0.15 (−0.35 to 0.05).ConclusionThis study suggests DCE-MRI derived measures of synovial enhancement may be more sensitive to the response to treatment and more strongly associated with changes in pain than synovial volume and may be better outcomes for assessment of structural effects of treatment in OA.

AB - ObjectiveSynovium is increasingly a target of osteoarthritis (OA) treatment, yet its optimal measurement is unclear. Using dynamic contrast enhanced (DCE) MRI in knee OA patients before and after intraarticular steroid injection, we compared the responsiveness of static synovial volume measures to measures of dynamic changes in synovial enhancement, changes that are strongly related to synovial vascularity.MethodsNinety three patients underwent DCE-MRI before and 1–2 weeks after intra-articular injection of 80 mg methylprednisolone. Synovium was segmented and volume, relative enhancement rate (RER), maximum relative enhancement (REmax), late relative enhancement (RElate) and pharmacokinetic parameters (Ktrans, ve) were calculated. KOOS (​knee injury and osteoarthritis outcome score) pain score was recorded before and after injection. Standardized change scores were calculated for each parameter. Linear regression and Pearson's correlations were used to investigate the relationship between change in MRI parameters and change in pain.ResultsThe change in standardized score for the measures of synovial enhancement, RElate and REmax were −0.58 (95% CI −0.79 to −0.37) and −0.62 (95% CI −0.83 to −0.41) respectively, whereas the score for synovial volume was −0.30 (−0.52 to −0.09). Further, change in knee pain correlated more strongly with changes in enhancement (for both REmax and RElate, r = −0.27 (95% CI −0.45 to −0.07)) than with changes in synovial volume −0.15 (−0.35 to 0.05).ConclusionThis study suggests DCE-MRI derived measures of synovial enhancement may be more sensitive to the response to treatment and more strongly associated with changes in pain than synovial volume and may be better outcomes for assessment of structural effects of treatment in OA.

U2 - 10.1016/j.joca.2016.03.015

DO - 10.1016/j.joca.2016.03.015

M3 - Article

VL - 24

SP - 1392

EP - 1398

JO - Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society

JF - Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society

SN - 1063-4584

IS - 8

ER -