Suzuki coupling of oxazoles

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A protocol for the functionalization of the oxazole 2- and 4-positions using the Suzuki coupling reaction is described. 2-Aryl-4-trifloyloxazoles undergo rapid, microwave-assisted coupling with a range of aryl and heteroaryl boronic acids in good to excellent yields. The methodology is similarly effective using 4-aryl-2-chlorooxazoles as the coupling partner and has been extended to the synthesis of a novel class of homo- and heterodimeric 4,4-linked dioxazoles. © 2006 American Chemical Society.

Bibliographical metadata

Original languageEnglish
Pages (from-to)2495-2498
Number of pages3
JournalOrganic Letters
Issue number12
Publication statusPublished - 8 Jun 2006