Substrate promiscuity of cytochrome P450 RhF

Research output: Contribution to journalArticle

  • External authors:
  • Elaine O'Reilly
  • Mark Corbett
  • Shahed Hussain
  • Paul P. Kelly
  • Dominique Richardson

Abstract

Cytochrome P450 RhF displays a high degree of substrate promiscuity, mediating a range of O-dealkylations, aromatic hydroxylations, epoxidations and asymmetric sulfoxidations. The self-sufficient nature of this CYP coupled with its ability to catalyse the oxidation of a wide range of functional groups highlights this enzyme as an excellent starting template for directed evolution and promising alternate to P450 BM3. © 2013 The Royal Society of Chemistry.

Bibliographical metadata

Original languageEnglish
Pages (from-to)1490-1492
Number of pages2
JournalCatalysis Science and Technology
Volume3
Issue number6
DOIs
Publication statusPublished - Jun 2013