Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography

Research output: Contribution to journalArticlepeer-review

  • External authors:
  • Christopher A. McDevitt
  • Chitra A. Shintre
  • J. Günter Grossmann
  • Naomi L. Pollock
  • Richard Callaghan

Abstract

P-glycoprotein (ABCB1) is an ATP-binding cassette protein that is associated with the acquisition of multi-drug resistance in cancer and the failure of chemotherapy in humans. Structural insights into this protein are described using a combination of small angle X-ray scattering data and cryo-electron crystallography data. We have compared the structures with bacterial homologues, and discuss the development of homology models for P-glycoprotein based on the bacterial Sav1866 structure. © 2008 Federation of European Biochemical Societies.

Bibliographical metadata

Original languageEnglish
Pages (from-to)2950-2956
Number of pages6
JournalFEBS Letters
Volume582
Issue number19
DOIs
Publication statusPublished - 20 Aug 2008