Stereospecific Coupling of Boronic Esters with N-Heteroaromatic Compounds

Research output: Research - peer-reviewArticle

  • Authors:
  • Josep Llaveria
  • Daniele Leonori
  • Varinder K Aggarwal


A protocol for the stereospecific coupling of chiral secondary and tertiary boronic esters with lithiated N-heteroaromatics is described. The process involves initial boronate complex formation followed by addition of Troc-Cl, which activates the nitrogen and induces 1,2-migration. Oxidative workup furnishes the coupled product with >98% es.

Bibliographical metadata

Original languageEnglish
Pages (from-to)10958-61
Number of pages4
JournalJournal of the American Chemical Society
Issue number34
StatePublished - 2 Sep 2015