Stereoselective synthesis of N-aryl proline amides by biotransformation- Ugi-Smiles sequence

Research output: Contribution to journalArticle

  • External authors:
  • Anass Znabet
  • Sara Blanken
  • Elwin Janssen
  • Frans J.J. De Kanter
  • Madeleine Helliwell
  • Eelco Ruijter
  • Romano V.A. Orru


An efficient combination of MAO-N-catalyzed desymmetrization of cyclic meso-amines with Ugi-Smiles multicomponent chemistry produced optically pure N-aryl proline amides. This method represents the first report of a fully asymmetric Ugi-Smiles process.

Bibliographical metadata

Original languageEnglish
Pages (from-to)941-944
Number of pages4
JournalOrganic and Biomolecular Chemistry
Issue number5
Publication statusPublished - 7 Feb 2012

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