Spatio-temporal regulation of gene expression defines subpopulations of epidermal stem cellsCitation formats

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Spatio-temporal regulation of gene expression defines subpopulations of epidermal stem cells. / Aruketty, Maneesha; Kurinna, Svitlana.

In: Biochemical Society Transactions, Vol. 48, No. 6, 18.12.2020, p. 2839-2850.

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Aruketty, Maneesha ; Kurinna, Svitlana. / Spatio-temporal regulation of gene expression defines subpopulations of epidermal stem cells. In: Biochemical Society Transactions. 2020 ; Vol. 48, No. 6. pp. 2839-2850.

Bibtex

@article{f60d58bff6084032ae3aac051342bb17,
title = "Spatio-temporal regulation of gene expression defines subpopulations of epidermal stem cells",
abstract = "The search for epidermal stem cells has gained the momentum as they possess unique biological characteristics and a potential in regeneration therapies. Several transcription factors and miRNAs have been identified as epidermal stem cell markers. However, the separation of epidermal stem cells from their progeny remains challenging. The introduction of single-cell transcriptomics pointed to the high degree of heterogeneity in epidermal stem cells imbedded within subpopulations of keratinocytes. Pseudotime inference, RNA velocity, and cellular entropy further enhanced our knowledge of stem cells, allowing for the discovery of the epidermal stem cell plasticity. We explore the main findings that lead to the discovery of the plastic trait within the epidermal stem cells and the implications of cell plasticity in regenerative medicine.",
author = "Maneesha Aruketty and Svitlana Kurinna",
note = "Funding Information: The work of our group is supported by the Medical Research Council Career Development Award and the University of Manchester (grant number R120531 to SK). Publisher Copyright: {\textcopyright} 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2020",
month = dec,
day = "18",
doi = "10.1042/BST20200740",
language = "English",
volume = "48",
pages = "2839--2850",
journal = "Biochemical Society. Transactions",
issn = "0300-5127",
publisher = "Portland Press Ltd",
number = "6",

}

RIS

TY - JOUR

T1 - Spatio-temporal regulation of gene expression defines subpopulations of epidermal stem cells

AU - Aruketty, Maneesha

AU - Kurinna, Svitlana

N1 - Funding Information: The work of our group is supported by the Medical Research Council Career Development Award and the University of Manchester (grant number R120531 to SK). Publisher Copyright: © 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2020/12/18

Y1 - 2020/12/18

N2 - The search for epidermal stem cells has gained the momentum as they possess unique biological characteristics and a potential in regeneration therapies. Several transcription factors and miRNAs have been identified as epidermal stem cell markers. However, the separation of epidermal stem cells from their progeny remains challenging. The introduction of single-cell transcriptomics pointed to the high degree of heterogeneity in epidermal stem cells imbedded within subpopulations of keratinocytes. Pseudotime inference, RNA velocity, and cellular entropy further enhanced our knowledge of stem cells, allowing for the discovery of the epidermal stem cell plasticity. We explore the main findings that lead to the discovery of the plastic trait within the epidermal stem cells and the implications of cell plasticity in regenerative medicine.

AB - The search for epidermal stem cells has gained the momentum as they possess unique biological characteristics and a potential in regeneration therapies. Several transcription factors and miRNAs have been identified as epidermal stem cell markers. However, the separation of epidermal stem cells from their progeny remains challenging. The introduction of single-cell transcriptomics pointed to the high degree of heterogeneity in epidermal stem cells imbedded within subpopulations of keratinocytes. Pseudotime inference, RNA velocity, and cellular entropy further enhanced our knowledge of stem cells, allowing for the discovery of the epidermal stem cell plasticity. We explore the main findings that lead to the discovery of the plastic trait within the epidermal stem cells and the implications of cell plasticity in regenerative medicine.

U2 - 10.1042/BST20200740

DO - 10.1042/BST20200740

M3 - Article

VL - 48

SP - 2839

EP - 2850

JO - Biochemical Society. Transactions

JF - Biochemical Society. Transactions

SN - 0300-5127

IS - 6

ER -