Solubility study of tobramycin in room temperature ionic liquids: An experimental and computational based study

Research output: Contribution to journalArticlepeer-review

  • Authors:
  • Christopher Hardacre
  • Richard Cunningham
  • Nancy Forero-Martinez
  • Tristan G. A. Youngs
  • Marie E. Migaud

Abstract

Herein, we present a computational and experimental study assessing the solubility of tobramycin 1 in a series of hydrophilic room temperature ionic liquids (RTIL). We show that hydrophilic ionic liquids, in particular those containing acetate, [OAc]-, enable significantly enhanced solubilisation of tobramycin in comparison to conventional molecular solvents.

Bibliographical metadata

Original languageEnglish
Pages (from-to)107214-107218
Number of pages5
JournalRSC Advances
Volume6
Issue number109
Early online date4 Nov 2016
DOIs
Publication statusPublished - 2016