Solid state dehydration processes: Mechanism of water loss from crystalline inosine dihydrate

Research output: Contribution to journalArticle

  • External authors:
  • Amy L. Gillon
  • Richard Storey
  • Neil Feeder
  • Gary Nichols
  • Geoffrey Dent
  • David C. Apperley


The solid state dehydration of inosine dihydrate has been investigated using powder X-ray diffraction, differential scanning calorimetry, thermal gravimetric analysis, dynamic vapor sorption, hot stage microscopy, 13C solid state NMR, and variable temperature Fourier transform infrared spectroscopy. The information obtained from these experiments has been combined with an analysis of the crystallographic packing of inosine dihydrate and its two anhydrous polymorphs to yield mechanistic insights into the modes of water loss. The results allow an understanding of why, surprisingly, the dehydration of the dihydrate is always found to give the anhydrous, metastable, α-form. © 2005 American Chemical Society.

Bibliographical metadata

Original languageEnglish
Pages (from-to)5341-5347
Number of pages6
JournalJournal of Physical Chemistry B
Issue number11
Publication statusPublished - 24 Mar 2005