Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times

Research output: Contribution to journalArticle

  • External authors:
  • Michael R. Chapman
  • Maria H.T. Kwan
  • Georgina King
  • Katherine E. Jolley
  • Mariam Hussain
  • Shahed Hussain
  • Ibrahim E. Salama
  • Carlos González Nino
  • Lisa A. Thompson
  • Mary E. Bayana
  • Adam D. Clayton
  • Bao N. Nguyen
  • Nikil Kapur
  • A. John Blacker


A universal multistage cascade CSTR has been developed that is suitable for a wide range of continuous-flow processes. Coined by our group the "Freactor" (free-to-access reactor), the new reactor integrates the efficiency of pipe-flow processing with the advanced mixing of a CSTR, delivering a general "plug-and-play" reactor platform which is well-suited to multiphasic continuous-flow chemistry. Importantly, the reactor geometry is easily customized to accommodate reactions requiring long residence times (≥3 h tested).

Bibliographical metadata

Original languageEnglish
Pages (from-to)1294-1301
Number of pages8
JournalOrganic Process Research and Development
Issue number9
Early online date28 Jun 2017
Publication statusPublished - 15 Sep 2017