Similar risk of cardiovascular events in idiopathic inflammatory myopathy and rheumatoid arthritis in the first 5 years after diagnosis.Citation formats

  • External authors:
  • Cristina Parraga Prieto
  • Fowzia Ibrahim
  • Richard Campbell
  • James Galloway
  • Patrick Gordon

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Similar risk of cardiovascular events in idiopathic inflammatory myopathy and rheumatoid arthritis in the first 5 years after diagnosis. / Parraga Prieto, Cristina ; Ibrahim, Fowzia; Campbell, Richard; Chinoy, Hector; Galloway, James; Gordon, Patrick.

In: Clinical Rheumatology, Vol. 40, No. 1, 22.06.2021, p. 231-238.

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Parraga Prieto, C, Ibrahim, F, Campbell, R, Chinoy, H, Galloway, J & Gordon, P 2021, 'Similar risk of cardiovascular events in idiopathic inflammatory myopathy and rheumatoid arthritis in the first 5 years after diagnosis.', Clinical Rheumatology, vol. 40, no. 1, pp. 231-238. https://doi.org/10.1007/s10067-020-05237-7

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Parraga Prieto, Cristina ; Ibrahim, Fowzia ; Campbell, Richard ; Chinoy, Hector ; Galloway, James ; Gordon, Patrick. / Similar risk of cardiovascular events in idiopathic inflammatory myopathy and rheumatoid arthritis in the first 5 years after diagnosis. In: Clinical Rheumatology. 2021 ; Vol. 40, No. 1. pp. 231-238.

Bibtex

@article{706a0afd1894441499ec9bfa8ce03343,
title = "Similar risk of cardiovascular events in idiopathic inflammatory myopathy and rheumatoid arthritis in the first 5 years after diagnosis.",
abstract = "Objectives: To estimate the incidence of cardiovascular (CV) events in idiopathic inflammatory myopathy (IIM) compared to patients with rheumatoid arthritis (RA) and the general population. To explore the contribution of traditional CV risk factors to any difference observed. Methods: A retrospective matched population-based cohort study was conducted using UK Clinical Practice Research Datalink (CPRD) from 1987-2013. The incidence of CV events was calculated for each cohort over time and compared using Cox proportional hazards models. Multivariable analyses were used to adjust for traditional CV risk factors.Results: 603 patients with IIM, 4047 RA and 4061 healthy controls were included. The rate of CV events in IIM was significantly greater than healthy controls [hazard ratio (HR) 1.47 (95% confidence interval (CI) 1.18-1.83)] and remained significant after adjustment for CV risk factors [HR 1.38 (95% CI 1.11-1.72)]. Risk was similar between IIM and RA [HR 1.01 (95% CI 0.78-1.31)]. The rate of myocardial infarction [HR 1.61 (95% CI 1.27-2.04)] but not stroke [HR 0.92 (95% CI 0.59-1.44)] was significantly greater in IIM compared to healthy controls. After the first 5 years, the rate of CV events for RA remained significantly greater compared to the control group, but appeared to return to that of the healthy controls in the IIM group.Conclusion: IIM is associated with an increased risk of CV events in the first five years after diagnosis similar to that of RA. Beyond five years, the risk appears to return to that of the general population in IIM but not RA. ",
keywords = "Idiopathic inflammatory myopathy, dermatomyositis, polymyositis, cardiovascular event, atherosclerosis",
author = "{Parraga Prieto}, Cristina and Fowzia Ibrahim and Richard Campbell and Hector Chinoy and James Galloway and Patrick Gordon",
note = "Funding Information: This work was supported by the Medical Research Council (grant number MR/N003322/1). The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health. Publisher Copyright: {\textcopyright} 2020, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
month = jun,
day = "22",
doi = "10.1007/s10067-020-05237-7",
language = "English",
volume = "40",
pages = "231--238",
journal = "Clinical Rheumatology",
issn = "0770-3198",
publisher = "Springer Nature",
number = "1",

}

RIS

TY - JOUR

T1 - Similar risk of cardiovascular events in idiopathic inflammatory myopathy and rheumatoid arthritis in the first 5 years after diagnosis.

AU - Parraga Prieto, Cristina

AU - Ibrahim, Fowzia

AU - Campbell, Richard

AU - Chinoy, Hector

AU - Galloway, James

AU - Gordon, Patrick

N1 - Funding Information: This work was supported by the Medical Research Council (grant number MR/N003322/1). The views expressed in this publication are those of the authors and not necessarily those of the NHS, the National Institute for Health Research or the Department of Health. Publisher Copyright: © 2020, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/6/22

Y1 - 2021/6/22

N2 - Objectives: To estimate the incidence of cardiovascular (CV) events in idiopathic inflammatory myopathy (IIM) compared to patients with rheumatoid arthritis (RA) and the general population. To explore the contribution of traditional CV risk factors to any difference observed. Methods: A retrospective matched population-based cohort study was conducted using UK Clinical Practice Research Datalink (CPRD) from 1987-2013. The incidence of CV events was calculated for each cohort over time and compared using Cox proportional hazards models. Multivariable analyses were used to adjust for traditional CV risk factors.Results: 603 patients with IIM, 4047 RA and 4061 healthy controls were included. The rate of CV events in IIM was significantly greater than healthy controls [hazard ratio (HR) 1.47 (95% confidence interval (CI) 1.18-1.83)] and remained significant after adjustment for CV risk factors [HR 1.38 (95% CI 1.11-1.72)]. Risk was similar between IIM and RA [HR 1.01 (95% CI 0.78-1.31)]. The rate of myocardial infarction [HR 1.61 (95% CI 1.27-2.04)] but not stroke [HR 0.92 (95% CI 0.59-1.44)] was significantly greater in IIM compared to healthy controls. After the first 5 years, the rate of CV events for RA remained significantly greater compared to the control group, but appeared to return to that of the healthy controls in the IIM group.Conclusion: IIM is associated with an increased risk of CV events in the first five years after diagnosis similar to that of RA. Beyond five years, the risk appears to return to that of the general population in IIM but not RA.

AB - Objectives: To estimate the incidence of cardiovascular (CV) events in idiopathic inflammatory myopathy (IIM) compared to patients with rheumatoid arthritis (RA) and the general population. To explore the contribution of traditional CV risk factors to any difference observed. Methods: A retrospective matched population-based cohort study was conducted using UK Clinical Practice Research Datalink (CPRD) from 1987-2013. The incidence of CV events was calculated for each cohort over time and compared using Cox proportional hazards models. Multivariable analyses were used to adjust for traditional CV risk factors.Results: 603 patients with IIM, 4047 RA and 4061 healthy controls were included. The rate of CV events in IIM was significantly greater than healthy controls [hazard ratio (HR) 1.47 (95% confidence interval (CI) 1.18-1.83)] and remained significant after adjustment for CV risk factors [HR 1.38 (95% CI 1.11-1.72)]. Risk was similar between IIM and RA [HR 1.01 (95% CI 0.78-1.31)]. The rate of myocardial infarction [HR 1.61 (95% CI 1.27-2.04)] but not stroke [HR 0.92 (95% CI 0.59-1.44)] was significantly greater in IIM compared to healthy controls. After the first 5 years, the rate of CV events for RA remained significantly greater compared to the control group, but appeared to return to that of the healthy controls in the IIM group.Conclusion: IIM is associated with an increased risk of CV events in the first five years after diagnosis similar to that of RA. Beyond five years, the risk appears to return to that of the general population in IIM but not RA.

KW - Idiopathic inflammatory myopathy

KW - dermatomyositis

KW - polymyositis

KW - cardiovascular event

KW - atherosclerosis

U2 - 10.1007/s10067-020-05237-7

DO - 10.1007/s10067-020-05237-7

M3 - Article

C2 - 32572804

VL - 40

SP - 231

EP - 238

JO - Clinical Rheumatology

JF - Clinical Rheumatology

SN - 0770-3198

IS - 1

ER -