Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse modelCitation formats

  • External authors:
  • Joanna L. Stanley
  • Irene J. Andersson
  • Rajan Poudel
  • Christian F. Rueda-Clausen
  • Sandra T. Davidge
  • Philip N. Baker

Standard

Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse model. / Stanley, Joanna L.; Andersson, Irene J.; Poudel, Rajan; Rueda-Clausen, Christian F.; Sibley, Colin P.; Davidge, Sandra T.; Baker, Philip N.

In: Hypertension, Vol. 59, No. 5, 05.2012, p. 1021-1028.

Research output: Contribution to journalArticle

Harvard

Stanley, JL, Andersson, IJ, Poudel, R, Rueda-Clausen, CF, Sibley, CP, Davidge, ST & Baker, PN 2012, 'Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse model', Hypertension, vol. 59, no. 5, pp. 1021-1028. https://doi.org/10.1161/HYPERTENSIONAHA.111.186270

APA

Stanley, J. L., Andersson, I. J., Poudel, R., Rueda-Clausen, C. F., Sibley, C. P., Davidge, S. T., & Baker, P. N. (2012). Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse model. Hypertension, 59(5), 1021-1028. https://doi.org/10.1161/HYPERTENSIONAHA.111.186270

Vancouver

Stanley JL, Andersson IJ, Poudel R, Rueda-Clausen CF, Sibley CP, Davidge ST et al. Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse model. Hypertension. 2012 May;59(5):1021-1028. https://doi.org/10.1161/HYPERTENSIONAHA.111.186270

Author

Stanley, Joanna L. ; Andersson, Irene J. ; Poudel, Rajan ; Rueda-Clausen, Christian F. ; Sibley, Colin P. ; Davidge, Sandra T. ; Baker, Philip N. / Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse model. In: Hypertension. 2012 ; Vol. 59, No. 5. pp. 1021-1028.

Bibtex

@article{6c24055e2cdd4d1a8653ec704b34b34c,
title = "Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse model",
abstract = "Preeclampsia and fetal growth restriction are responsible for the majority of maternal and perinatal morbidity and mortality associated with complicated pregnancies. Although their etiologies are complex and multifactorial, both are associated with increased uterine artery resistance. Sildenafil citrate is able to rescue the dysfunction observed ex vivo in uterine arteries of women with preeclampsia. The ability of sildenafil citrate to increase uterine artery vasodilation, thereby decreasing uterine artery resistance and, hence, ameliorated preeclampsia and fetal growth restriction, was tested in a mouse model of preeclampsia, the catechol-O-methyl transferase knockout mouse (COMT -/-). COMT -/- and C57BL/6J mice were treated (0.2 mg/mL in drinking water, n=6-12) from gestational day 12.5 to 18.5. Measures of pup growth, including body weight, crown/rump length, and abdominal circumference, were reduced in COMT -/- mice; this was normalized after treatment with Sildenafil. COMT -/- mice also demonstrated abnormal umbilical Doppler waveforms, including reverse arterial blood flow velocity. This was normalized after treatment with Sildenafil. Abnormal uterine artery Doppler waveforms were not demonstrated in COMT -/- mice, although ex vivo responses of uterine arteries to phenylephrine were increased; moreover, treatment with Sildenafil did improve ex vivo sensitivity to an endothelium-dependent vasodilator. The data presented here demonstrate that Sildenafil can rescue pup growth and improve abnormal umbilical Doppler waveforms, providing support for a potential new therapeutic strategy targeting fetal growth restriction. {\textcopyright} 2012 American Heart Association, Inc.",
keywords = "Fetal growth restriction, Mice, Preeclampsia, Umbilical artery, Uterine artery",
author = "Stanley, {Joanna L.} and Andersson, {Irene J.} and Rajan Poudel and Rueda-Clausen, {Christian F.} and Sibley, {Colin P.} and Davidge, {Sandra T.} and Baker, {Philip N.}",
note = "Stanley, Joanna L Andersson, Irene J Poudel, Rajan Rueda-Clausen, Christian F Sibley, Colin P Davidge, Sandra T Baker, Philip N Medical Research Council/United Kingdom Comparative Study Research Support, Non-U.S. Gov't United States Hypertension Hypertension. 2012 May;59(5):1021-8. Epub 2012 Mar 5.",
year = "2012",
month = may
doi = "10.1161/HYPERTENSIONAHA.111.186270",
language = "English",
volume = "59",
pages = "1021--1028",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams & Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - Sildenafil citrate rescues fetal growth in the catechol-O-methyl transferase knockout mouse model

AU - Stanley, Joanna L.

AU - Andersson, Irene J.

AU - Poudel, Rajan

AU - Rueda-Clausen, Christian F.

AU - Sibley, Colin P.

AU - Davidge, Sandra T.

AU - Baker, Philip N.

N1 - Stanley, Joanna L Andersson, Irene J Poudel, Rajan Rueda-Clausen, Christian F Sibley, Colin P Davidge, Sandra T Baker, Philip N Medical Research Council/United Kingdom Comparative Study Research Support, Non-U.S. Gov't United States Hypertension Hypertension. 2012 May;59(5):1021-8. Epub 2012 Mar 5.

PY - 2012/5

Y1 - 2012/5

N2 - Preeclampsia and fetal growth restriction are responsible for the majority of maternal and perinatal morbidity and mortality associated with complicated pregnancies. Although their etiologies are complex and multifactorial, both are associated with increased uterine artery resistance. Sildenafil citrate is able to rescue the dysfunction observed ex vivo in uterine arteries of women with preeclampsia. The ability of sildenafil citrate to increase uterine artery vasodilation, thereby decreasing uterine artery resistance and, hence, ameliorated preeclampsia and fetal growth restriction, was tested in a mouse model of preeclampsia, the catechol-O-methyl transferase knockout mouse (COMT -/-). COMT -/- and C57BL/6J mice were treated (0.2 mg/mL in drinking water, n=6-12) from gestational day 12.5 to 18.5. Measures of pup growth, including body weight, crown/rump length, and abdominal circumference, were reduced in COMT -/- mice; this was normalized after treatment with Sildenafil. COMT -/- mice also demonstrated abnormal umbilical Doppler waveforms, including reverse arterial blood flow velocity. This was normalized after treatment with Sildenafil. Abnormal uterine artery Doppler waveforms were not demonstrated in COMT -/- mice, although ex vivo responses of uterine arteries to phenylephrine were increased; moreover, treatment with Sildenafil did improve ex vivo sensitivity to an endothelium-dependent vasodilator. The data presented here demonstrate that Sildenafil can rescue pup growth and improve abnormal umbilical Doppler waveforms, providing support for a potential new therapeutic strategy targeting fetal growth restriction. © 2012 American Heart Association, Inc.

AB - Preeclampsia and fetal growth restriction are responsible for the majority of maternal and perinatal morbidity and mortality associated with complicated pregnancies. Although their etiologies are complex and multifactorial, both are associated with increased uterine artery resistance. Sildenafil citrate is able to rescue the dysfunction observed ex vivo in uterine arteries of women with preeclampsia. The ability of sildenafil citrate to increase uterine artery vasodilation, thereby decreasing uterine artery resistance and, hence, ameliorated preeclampsia and fetal growth restriction, was tested in a mouse model of preeclampsia, the catechol-O-methyl transferase knockout mouse (COMT -/-). COMT -/- and C57BL/6J mice were treated (0.2 mg/mL in drinking water, n=6-12) from gestational day 12.5 to 18.5. Measures of pup growth, including body weight, crown/rump length, and abdominal circumference, were reduced in COMT -/- mice; this was normalized after treatment with Sildenafil. COMT -/- mice also demonstrated abnormal umbilical Doppler waveforms, including reverse arterial blood flow velocity. This was normalized after treatment with Sildenafil. Abnormal uterine artery Doppler waveforms were not demonstrated in COMT -/- mice, although ex vivo responses of uterine arteries to phenylephrine were increased; moreover, treatment with Sildenafil did improve ex vivo sensitivity to an endothelium-dependent vasodilator. The data presented here demonstrate that Sildenafil can rescue pup growth and improve abnormal umbilical Doppler waveforms, providing support for a potential new therapeutic strategy targeting fetal growth restriction. © 2012 American Heart Association, Inc.

KW - Fetal growth restriction

KW - Mice

KW - Preeclampsia

KW - Umbilical artery

KW - Uterine artery

U2 - 10.1161/HYPERTENSIONAHA.111.186270

DO - 10.1161/HYPERTENSIONAHA.111.186270

M3 - Article

VL - 59

SP - 1021

EP - 1028

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 5

ER -