Severely photosensitive psoriasis: A phenotypically defined patient subsetCitation formats

  • External authors:
  • Kirsty J. Rutter
  • Lindsey F. Cotterell
  • Thomas Brenn

Standard

Severely photosensitive psoriasis: A phenotypically defined patient subset. / Rutter, Kirsty J.; Watson, Rachel E B; Cotterell, Lindsey F.; Brenn, Thomas; Griffiths, Christopher E M; Rhodes, Lesley E.

In: Journal of Investigative Dermatology, Vol. 129, No. 12, 2009, p. 2861-2867.

Research output: Contribution to journalArticlepeer-review

Harvard

Rutter, KJ, Watson, REB, Cotterell, LF, Brenn, T, Griffiths, CEM & Rhodes, LE 2009, 'Severely photosensitive psoriasis: A phenotypically defined patient subset', Journal of Investigative Dermatology, vol. 129, no. 12, pp. 2861-2867. https://doi.org/10.1038/jid.2009.156

APA

Rutter, K. J., Watson, R. E. B., Cotterell, L. F., Brenn, T., Griffiths, C. E. M., & Rhodes, L. E. (2009). Severely photosensitive psoriasis: A phenotypically defined patient subset. Journal of Investigative Dermatology, 129(12), 2861-2867. https://doi.org/10.1038/jid.2009.156

Vancouver

Author

Rutter, Kirsty J. ; Watson, Rachel E B ; Cotterell, Lindsey F. ; Brenn, Thomas ; Griffiths, Christopher E M ; Rhodes, Lesley E. / Severely photosensitive psoriasis: A phenotypically defined patient subset. In: Journal of Investigative Dermatology. 2009 ; Vol. 129, No. 12. pp. 2861-2867.

Bibtex

@article{a6dc5a75fbc64f8892035dab014d19e1,
title = "Severely photosensitive psoriasis: A phenotypically defined patient subset",
abstract = "A subset of patients with chronic plaque psoriasis exhibits severely photosensitive psoriasis (PP) with a pronounced seasonal pattern, but the pathomechanism is not understood. We performed two related studies; first, a detailed clinical characterization of PP, and second, a controlled investigation exploring the underlying pathomechanisms through the assessment of disease onset after photoprovocation. Patients with PP (n=20) showed striking female predominance (19F:1M), very low mean age of psoriasis onset (11 years, range 2-24), family history of psoriasis (13/20), a strong HLA-Cw * 0602 association (16/17), and a rapid abnormal clinical response to broadband UVA, comprising erythema±scaling plaques (17/20). Subsequently, patients with PP (n=10), non-PP (n=9), and healthy volunteers (n=11) were challenged with low-dose broadband UVA on 3 consecutive days, and serial biopsies were taken after 6 hours to 7 days and from unchallenged skin. Histological changes consistent with early psoriasis occurred in 4 of 10 PP patients, but in neither of the control groups, with significant dermal infiltration by neutrophils, CD4 +, CD8 +, and CD45RO + cells at 24 h, accompanied by acanthosis. Thus, a phenotypically distinct subset of psoriasis has been characterized. In contrast with earlier assumptions, UV can provoke psoriasiform features rapidly de novo; a role for memory effector T cells is supported in the early phase. {\textcopyright} 2009 The Society for Investigative Dermatology.",
author = "Rutter, {Kirsty J.} and Watson, {Rachel E B} and Cotterell, {Lindsey F.} and Thomas Brenn and Griffiths, {Christopher E M} and Rhodes, {Lesley E.}",
year = "2009",
doi = "10.1038/jid.2009.156",
language = "English",
volume = "129",
pages = "2861--2867",
journal = "The Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Springer Nature",
number = "12",

}

RIS

TY - JOUR

T1 - Severely photosensitive psoriasis: A phenotypically defined patient subset

AU - Rutter, Kirsty J.

AU - Watson, Rachel E B

AU - Cotterell, Lindsey F.

AU - Brenn, Thomas

AU - Griffiths, Christopher E M

AU - Rhodes, Lesley E.

PY - 2009

Y1 - 2009

N2 - A subset of patients with chronic plaque psoriasis exhibits severely photosensitive psoriasis (PP) with a pronounced seasonal pattern, but the pathomechanism is not understood. We performed two related studies; first, a detailed clinical characterization of PP, and second, a controlled investigation exploring the underlying pathomechanisms through the assessment of disease onset after photoprovocation. Patients with PP (n=20) showed striking female predominance (19F:1M), very low mean age of psoriasis onset (11 years, range 2-24), family history of psoriasis (13/20), a strong HLA-Cw * 0602 association (16/17), and a rapid abnormal clinical response to broadband UVA, comprising erythema±scaling plaques (17/20). Subsequently, patients with PP (n=10), non-PP (n=9), and healthy volunteers (n=11) were challenged with low-dose broadband UVA on 3 consecutive days, and serial biopsies were taken after 6 hours to 7 days and from unchallenged skin. Histological changes consistent with early psoriasis occurred in 4 of 10 PP patients, but in neither of the control groups, with significant dermal infiltration by neutrophils, CD4 +, CD8 +, and CD45RO + cells at 24 h, accompanied by acanthosis. Thus, a phenotypically distinct subset of psoriasis has been characterized. In contrast with earlier assumptions, UV can provoke psoriasiform features rapidly de novo; a role for memory effector T cells is supported in the early phase. © 2009 The Society for Investigative Dermatology.

AB - A subset of patients with chronic plaque psoriasis exhibits severely photosensitive psoriasis (PP) with a pronounced seasonal pattern, but the pathomechanism is not understood. We performed two related studies; first, a detailed clinical characterization of PP, and second, a controlled investigation exploring the underlying pathomechanisms through the assessment of disease onset after photoprovocation. Patients with PP (n=20) showed striking female predominance (19F:1M), very low mean age of psoriasis onset (11 years, range 2-24), family history of psoriasis (13/20), a strong HLA-Cw * 0602 association (16/17), and a rapid abnormal clinical response to broadband UVA, comprising erythema±scaling plaques (17/20). Subsequently, patients with PP (n=10), non-PP (n=9), and healthy volunteers (n=11) were challenged with low-dose broadband UVA on 3 consecutive days, and serial biopsies were taken after 6 hours to 7 days and from unchallenged skin. Histological changes consistent with early psoriasis occurred in 4 of 10 PP patients, but in neither of the control groups, with significant dermal infiltration by neutrophils, CD4 +, CD8 +, and CD45RO + cells at 24 h, accompanied by acanthosis. Thus, a phenotypically distinct subset of psoriasis has been characterized. In contrast with earlier assumptions, UV can provoke psoriasiform features rapidly de novo; a role for memory effector T cells is supported in the early phase. © 2009 The Society for Investigative Dermatology.

U2 - 10.1038/jid.2009.156

DO - 10.1038/jid.2009.156

M3 - Article

C2 - 19536141

VL - 129

SP - 2861

EP - 2867

JO - The Journal of Investigative Dermatology

JF - The Journal of Investigative Dermatology

SN - 0022-202X

IS - 12

ER -