Severely photosensitive psoriasis: A phenotypically defined patient subset

Research output: Contribution to journalArticle

  • External authors:
  • Kirsty J. Rutter
  • Lindsey F. Cotterell
  • Thomas Brenn

Abstract

A subset of patients with chronic plaque psoriasis exhibits severely photosensitive psoriasis (PP) with a pronounced seasonal pattern, but the pathomechanism is not understood. We performed two related studies; first, a detailed clinical characterization of PP, and second, a controlled investigation exploring the underlying pathomechanisms through the assessment of disease onset after photoprovocation. Patients with PP (n=20) showed striking female predominance (19F:1M), very low mean age of psoriasis onset (11 years, range 2-24), family history of psoriasis (13/20), a strong HLA-Cw * 0602 association (16/17), and a rapid abnormal clinical response to broadband UVA, comprising erythema±scaling plaques (17/20). Subsequently, patients with PP (n=10), non-PP (n=9), and healthy volunteers (n=11) were challenged with low-dose broadband UVA on 3 consecutive days, and serial biopsies were taken after 6 hours to 7 days and from unchallenged skin. Histological changes consistent with early psoriasis occurred in 4 of 10 PP patients, but in neither of the control groups, with significant dermal infiltration by neutrophils, CD4 +, CD8 +, and CD45RO + cells at 24 h, accompanied by acanthosis. Thus, a phenotypically distinct subset of psoriasis has been characterized. In contrast with earlier assumptions, UV can provoke psoriasiform features rapidly de novo; a role for memory effector T cells is supported in the early phase. © 2009 The Society for Investigative Dermatology.

Bibliographical metadata

Original languageEnglish
Pages (from-to)2861-2867
Number of pages6
JournalJournal of Investigative Dermatology
Volume129
Issue number12
DOIs
Publication statusPublished - 2009