Seven challenges in modeling pathogen dynamics within-host and across scales

Research output: Contribution to journalArticle

  • External authors:
  • Julia R. Gog
  • James L. N. Wood
  • Angela R. McLean
  • Nimalan Arinaminpathy
  • James O. Lloyd-Smith

Abstract

The population dynamics of infectious disease is a mature field in terms of theory and to some extent, application. However for microparasites, the theory and application of models of the dynamics within a single infected host is still an open field. Further, connecting across the scales – from cellular to host level, to population level – has potential to vastly improve our understanding of pathogen dynamics and evolution. Here, we highlight seven challenges in the following areas: transmission bottlenecks, heterogeneity within host, dynamic fitness landscapes within hosts, making use of next-generation sequencing data, capturing superinfection and when and how to model more than two scales.

Bibliographical metadata

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalEpidemics
Volume10
DOIs
Publication statusPublished - Mar 2015