Selective Construction of Quaternary Stereocentres in Radical Cyclisation Cascades triggered by electron-transfer reduction of amide-type carbonyls

Research output: Contribution to journalArticle

Abstract

Radical–radical cyclisation cascades, triggered by single-electron-transfer to amide-type carbonyls using SmI2–H2O–LiBr, result in the selective construction of quaternary carbon stereocentres. The cascades deliver tricyclic barbiturates with four stereocentres in good yield and with excellent diastereocontrol.

Bibliographical metadata

Original languageEnglish
Pages (from-to)4159-4164
Number of pages6
JournalOrganic and Biomolecular Chemistry
Volume15
Early online date12 Apr 2017
DOIs
Publication statusPublished - 2017