Seafood is expected to become increasingly important in future food systems and healthy diets. This transition will require the seafood sector to adapt business practices to respond to environmental and social challenges while increasing resilience. Here, we develop the Circular Economy-Resilience Framework for Business Models (CERF-BM) and, through exploring current literature, apply this framework to business models in the seafood sector. We find that the majority of business models incorporate elements of circular economy and resilience in a limited way. The reviewed business models often fail to consider other supply chain actors and, instead, focus on the business itself and its customers. The CERF-BM helps to elucidate this disconnect through assessing business models against company-level actions towards circularity in combination with systems-level resilience mechanisms. To reap the synergies between the circular economy and resilience mechanisms, seafood businesses could extract more value from organic waste and dematerialise their business models.