Scalable synthesis of multicolour conjugated polymer nanoparticles via Suzuki-Miyaura polymerisation in a miniemulsion and application in bioimaging.

Research output: Research - peer-reviewArticle

  • External authors:
  • Jonathan M. Behrendt
  • Jair A. Esquivel Guzman
  • Laura Purdie
  • Helen Willcock
  • John J. Morrison
  • Rachel K. O'Reilly
  • Mark C. McCairn

Abstract

Suzuki cross-coupling polymn. of aryldibromides and aryldiboronate esters in a sodium dodecyl sulfate (SDS)-stabilized miniemulsion provides a versatile and direct route to fluorescent conjugated polymer nanoparticles (CPNs). These nanoparticles have a conjugated backbone based on poly(9,9-dioctylfluorene) (PFO), however, significant structural diversity is introduced by incorporation of electron withdrawing, heterocyclic comonomers (5-50 mol.%) in order to tune the emission wavelengths from blue to far-red/near-IR. The robust nature of the polymn. methodol. allows for rapid assessment of the relationship between polymer compn., chain morphol. and optical properties of the resultant CPNs. Moreover, the CPNs (after a simple and rapid purifn. step) can be used directly in fluorescence-based intracellular labeling expts. (in HCT116 cells), in which they display low cytotoxicity at biol.-useful concns. [on SciFinder(R)]

Bibliographical metadata

Original languageEnglish
Pages (from-to)69-77
Number of pages9
JournalReactive & Functional Polymers
Volume107
DOIs
StatePublished - 30 Aug 2016