SAMHD1 sheds moonlight on DNA double-strand break repair

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SAMHD1 is known for its antiviral activity of hydrolysing deoxynucleotides required for virus replication. Daddacha et al. identify a hydrolase-independent, moonlighting function of SAMHD1 that facilitates homologous recombination of DNA double-strand breaks by promoting recruitment of CTIP, a DNA-end resection factor, to damaged DNA. These findings could benefit anti-cancer treatment.

Bibliographical metadata

Original languageEnglish
JournalTrends in genetics : TIG
Publication statusPublished - 30 Sep 2017