Same-day repeatability of fractional exhaled nitric oxide in severe asthmaCitation formats

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Same-day repeatability of fractional exhaled nitric oxide in severe asthma. / Wang, Ran; Alahmadi, Fahad; Niven, Robert; Fowler, Stephen J.

In: European Respiratory Journal, 04.02.2021.

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Wang, Ran ; Alahmadi, Fahad ; Niven, Robert ; Fowler, Stephen J. / Same-day repeatability of fractional exhaled nitric oxide in severe asthma. In: European Respiratory Journal. 2021.

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@article{40f808bdcf1c4d9590982de099e02edd,
title = "Same-day repeatability of fractional exhaled nitric oxide in severe asthma",
abstract = "Fractional exhaled nitric oxide (FeNO) is a single-breath test used in asthma diagnosis and management. Whilst a number of studies in mild to moderate asthma have demonstrated excellent repeatability of FeNO by assessing intra-device reproducibility from consecutive blows [1–3], the between-session and diurnal variability have been inconsistent [4–9]. Asthma is a highly variable disease. The excessive diurnal variability in airflow obstruction is a marker for disease severity, poor control and mortality. Diurnal variability of FeNO is also a predictor for poor asthma control [8]. We have demonstrated that FeNO has a significant time-of-the-day difference with a median of 12 parts per billion (ppb) between peak and trough readings within a 24-hour cycle in stable mild/moderate asthma [10]; whether this same-day variation is clinically significant in the diagnosis and management of asthma remains unclear. FeNO has been readily used in the monitoring of severe asthma, but its same-day reproducibility as a single-breath test is unknown in this group.",
author = "Ran Wang and Fahad Alahmadi and Robert Niven and Fowler, {Stephen J}",
year = "2021",
month = feb,
day = "4",
doi = "10.1183/13993003.03391-2020",
language = "English",
journal = "The European respiratory journal",
issn = "0903-1936",
publisher = "European Respiratory Society",

}

RIS

TY - JOUR

T1 - Same-day repeatability of fractional exhaled nitric oxide in severe asthma

AU - Wang, Ran

AU - Alahmadi, Fahad

AU - Niven, Robert

AU - Fowler, Stephen J

PY - 2021/2/4

Y1 - 2021/2/4

N2 - Fractional exhaled nitric oxide (FeNO) is a single-breath test used in asthma diagnosis and management. Whilst a number of studies in mild to moderate asthma have demonstrated excellent repeatability of FeNO by assessing intra-device reproducibility from consecutive blows [1–3], the between-session and diurnal variability have been inconsistent [4–9]. Asthma is a highly variable disease. The excessive diurnal variability in airflow obstruction is a marker for disease severity, poor control and mortality. Diurnal variability of FeNO is also a predictor for poor asthma control [8]. We have demonstrated that FeNO has a significant time-of-the-day difference with a median of 12 parts per billion (ppb) between peak and trough readings within a 24-hour cycle in stable mild/moderate asthma [10]; whether this same-day variation is clinically significant in the diagnosis and management of asthma remains unclear. FeNO has been readily used in the monitoring of severe asthma, but its same-day reproducibility as a single-breath test is unknown in this group.

AB - Fractional exhaled nitric oxide (FeNO) is a single-breath test used in asthma diagnosis and management. Whilst a number of studies in mild to moderate asthma have demonstrated excellent repeatability of FeNO by assessing intra-device reproducibility from consecutive blows [1–3], the between-session and diurnal variability have been inconsistent [4–9]. Asthma is a highly variable disease. The excessive diurnal variability in airflow obstruction is a marker for disease severity, poor control and mortality. Diurnal variability of FeNO is also a predictor for poor asthma control [8]. We have demonstrated that FeNO has a significant time-of-the-day difference with a median of 12 parts per billion (ppb) between peak and trough readings within a 24-hour cycle in stable mild/moderate asthma [10]; whether this same-day variation is clinically significant in the diagnosis and management of asthma remains unclear. FeNO has been readily used in the monitoring of severe asthma, but its same-day reproducibility as a single-breath test is unknown in this group.

U2 - 10.1183/13993003.03391-2020

DO - 10.1183/13993003.03391-2020

M3 - Article

C2 - 33542054

JO - The European respiratory journal

JF - The European respiratory journal

SN - 0903-1936

ER -