S-, N-, and Se-difluoromethylation using sodium chlorodifluoroacetate

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A simple protocol for the difluoromethylation of thiols is reported using chlorodifluoroacetate as the difluoromethylating agent. This cheap reagent undergoes smooth decarboxylation at 95 C to afford difluorocarbene, which can be trapped with a variety of aromatic and heteroaromatic thiols. The reaction is also effective for the difluoromethylation of heterocyclic nitrogen compounds and phenylselenol. © 2013 American Chemical Society.

Bibliographical metadata

Original languageEnglish
Pages (from-to)5036-5039
Number of pages3
JournalOrganic Letters
Issue number19
StatePublished - 4 Oct 2013

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