Ruthenium-Catalyzed C–H Arylation of Benzoic Acids and Indole Carboxylic Acids with Aryl Halides

Research output: Contribution to journalArticle

  • Authors:
  • Marco Simonetti
  • Diego Cannas
  • Adyasha Panigrahi
  • Szymon Kujawa
  • Michal Kryjewski
  • And 2 others
  • External authors:
  • Pan Xie
  • Igor Larrosa


Herein we report the first Ru-catalyzed C–H arylation of benzoic acids with readily available aryl (pseudo)halides. The reaction, which does not require the use of silver salt additives, allows the arylation of previously challenging hindered benzoic acids and the use of generally unreactive ortho-substituted halorarenes. Furthermore, our new protocol can efficiently be applied to indole carboxylic acids, thus allowing access to C7-, C6-, C5- and C4-arylated indole compounds, a departure from the classical enhanced reactivity of the C2 and C3 positions of indole.

Bibliographical metadata

Original languageEnglish
Pages (from-to)549-553
Number of pages5
JournalChemistry: A European Journal
Issue number3
Early online date5 Dec 2016
Publication statusPublished - 12 Jan 2017