RUNX1 marks a luminal castration resistant lineage established at the onset of prostate developmentCitation formats

  • External authors:
  • Renaud Mevel
  • Ivana Steiner
  • Susan Mason
  • Laura C. A. Galbraith
  • Rahima Patel
  • Muhammad Fadlullah Wilmot
  • Imran Ahmad
  • Hing Leung
  • Pedro Oliveira
  • Karen Blyth
  • Esther Baena

Standard

RUNX1 marks a luminal castration resistant lineage established at the onset of prostate development. / Mevel, Renaud; Steiner, Ivana; Mason, Susan; Galbraith, Laura C. A.; Patel, Rahima; Fadlullah Wilmot, Muhammad; Ahmad, Imran; Leung, Hing; Oliveira, Pedro; Blyth, Karen; Baena , Esther; Lacaud, Georges.

In: eLife, 07.10.2020.

Research output: Contribution to journalArticlepeer-review

Harvard

Mevel, R, Steiner, I, Mason, S, Galbraith, LCA, Patel, R, Fadlullah Wilmot, M, Ahmad, I, Leung, H, Oliveira, P, Blyth, K, Baena , E & Lacaud, G 2020, 'RUNX1 marks a luminal castration resistant lineage established at the onset of prostate development', eLife.

APA

Mevel, R., Steiner, I., Mason, S., Galbraith, L. C. A., Patel, R., Fadlullah Wilmot, M., Ahmad, I., Leung, H., Oliveira, P., Blyth, K., Baena , E., & Lacaud, G. (Accepted/In press). RUNX1 marks a luminal castration resistant lineage established at the onset of prostate development. eLife.

Vancouver

Mevel R, Steiner I, Mason S, Galbraith LCA, Patel R, Fadlullah Wilmot M et al. RUNX1 marks a luminal castration resistant lineage established at the onset of prostate development. eLife. 2020 Oct 7.

Author

Mevel, Renaud ; Steiner, Ivana ; Mason, Susan ; Galbraith, Laura C. A. ; Patel, Rahima ; Fadlullah Wilmot, Muhammad ; Ahmad, Imran ; Leung, Hing ; Oliveira, Pedro ; Blyth, Karen ; Baena , Esther ; Lacaud, Georges. / RUNX1 marks a luminal castration resistant lineage established at the onset of prostate development. In: eLife. 2020.

Bibtex

@article{e405672f423b4e228568c7a3d32dd463,
title = "RUNX1 marks a luminal castration resistant lineage established at the onset of prostate development",
abstract = "The characterization of prostate epithelial hierarchy and lineage heterogeneity is critical to understand its regenerative properties and malignancies. Here, we report that the transcription factor RUNX1 marks a specific subpopulation of proximal luminal cells (PLCs), enriched in the periurethral region of the developing and adult mouse prostate, and distinct from the previously identified NKX3.1+ luminal castration resistant cells. Using scRNA-seq profiling and genetic lineage tracing, we show that RUNX1+ PLCs are unaffected by androgen deprivation, and do not contribute to the regeneration of the distal luminal compartments. Furthermore, we demonstrate that a transcriptionally similar RUNX1+ population emerges at the onset of embryonic prostate specification to populate the proximal region of the ducts. Collectively, our results reveal that RUNX1+ PLCs is an intrinsic castration-resistant and self-sustained lineage that emerges early during prostate development and provide new insights into the lineage relationships of the prostate epithelium.",
author = "Renaud Mevel and Ivana Steiner and Susan Mason and Galbraith, {Laura C. A.} and Rahima Patel and {Fadlullah Wilmot}, Muhammad and Imran Ahmad and Hing Leung and Pedro Oliveira and Karen Blyth and Esther Baena and Georges Lacaud",
year = "2020",
month = oct,
day = "7",
language = "English",
journal = "eLife",
issn = "2050-084X",
publisher = "eLife Sciences Publications",

}

RIS

TY - JOUR

T1 - RUNX1 marks a luminal castration resistant lineage established at the onset of prostate development

AU - Mevel, Renaud

AU - Steiner, Ivana

AU - Mason, Susan

AU - Galbraith, Laura C. A.

AU - Patel, Rahima

AU - Fadlullah Wilmot, Muhammad

AU - Ahmad, Imran

AU - Leung, Hing

AU - Oliveira, Pedro

AU - Blyth, Karen

AU - Baena , Esther

AU - Lacaud, Georges

PY - 2020/10/7

Y1 - 2020/10/7

N2 - The characterization of prostate epithelial hierarchy and lineage heterogeneity is critical to understand its regenerative properties and malignancies. Here, we report that the transcription factor RUNX1 marks a specific subpopulation of proximal luminal cells (PLCs), enriched in the periurethral region of the developing and adult mouse prostate, and distinct from the previously identified NKX3.1+ luminal castration resistant cells. Using scRNA-seq profiling and genetic lineage tracing, we show that RUNX1+ PLCs are unaffected by androgen deprivation, and do not contribute to the regeneration of the distal luminal compartments. Furthermore, we demonstrate that a transcriptionally similar RUNX1+ population emerges at the onset of embryonic prostate specification to populate the proximal region of the ducts. Collectively, our results reveal that RUNX1+ PLCs is an intrinsic castration-resistant and self-sustained lineage that emerges early during prostate development and provide new insights into the lineage relationships of the prostate epithelium.

AB - The characterization of prostate epithelial hierarchy and lineage heterogeneity is critical to understand its regenerative properties and malignancies. Here, we report that the transcription factor RUNX1 marks a specific subpopulation of proximal luminal cells (PLCs), enriched in the periurethral region of the developing and adult mouse prostate, and distinct from the previously identified NKX3.1+ luminal castration resistant cells. Using scRNA-seq profiling and genetic lineage tracing, we show that RUNX1+ PLCs are unaffected by androgen deprivation, and do not contribute to the regeneration of the distal luminal compartments. Furthermore, we demonstrate that a transcriptionally similar RUNX1+ population emerges at the onset of embryonic prostate specification to populate the proximal region of the ducts. Collectively, our results reveal that RUNX1+ PLCs is an intrinsic castration-resistant and self-sustained lineage that emerges early during prostate development and provide new insights into the lineage relationships of the prostate epithelium.

M3 - Article

JO - eLife

JF - eLife

SN - 2050-084X

ER -