Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage.

Research output: Contribution to journalArticle

  • External authors:
  • Mario Di Napoli
  • Joshua N Goldstein
  • Floris H B M Schreuder
  • Sami Tetri
  • Turgut Tatlisumak
  • Bernard Yan
  • Koen M van Nieuwenhuizen
  • Nelly Dequatre-Ponchelle
  • Matthew Lee-Archer
  • Solveig Horstmann
  • Duncan Wilson
  • Fulvio Pomero
  • Luca Masotti
  • Christine Lerpiniere
  • Daniel Augustin Godoy
  • Abigail S Cohen
  • Rik Houben
  • Rustam Al-Shahi Salman
  • Paolo Pennati
  • Luigi Fenoglio
  • David Werring
  • Roland Veltkamp
  • Edith Wood
  • Helen M Dewey
  • Charlotte Cordonnier
  • Catharina J M Klijn
  • Fabrizio Meligeni
  • Stephen M Davis
  • Juha Huhtakangas
  • Julie Staals
  • Jonathan Rosand
  • Atte Meretoja


OBJECTIVE: There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case-fatality with different reversal strategies. METHODS: We pooled individual ICH patient data from 16 stroke registries in 9 countries (n=10 282) of whom 1797 (17%) were on VKA. After excluding 250 patients with INR

Bibliographical metadata

Original languageEnglish
JournalAnnals of Neurology
Publication statusPublished - 8 Apr 2015

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