Revealing and quantifying the impaired phonological analysis underpinning impaired comprehension in Wernicke's aphasiaCitation formats

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Revealing and quantifying the impaired phonological analysis underpinning impaired comprehension in Wernicke's aphasia. / Robson, Holly; Keidel, James L.; Lambon Ralph, Matthew A.; Sage, Karen.

In: NEUROPSYCHOLOGIA, Vol. 50, No. 2, 01.2012, p. 276-288.

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Robson, Holly ; Keidel, James L. ; Lambon Ralph, Matthew A. ; Sage, Karen. / Revealing and quantifying the impaired phonological analysis underpinning impaired comprehension in Wernicke's aphasia. In: NEUROPSYCHOLOGIA. 2012 ; Vol. 50, No. 2. pp. 276-288.

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@article{221409df727c407d8a31be162a3ff34f,
title = "Revealing and quantifying the impaired phonological analysis underpinning impaired comprehension in Wernicke's aphasia",
abstract = "Wernicke's aphasia is a condition which results in severely disrupted language comprehension following a lesion to the left temporo-parietal region. A phonological analysis deficit has traditionally been held to be at the root of the comprehension impairment in Wernicke's aphasia, a view consistent with current functional neuroimaging which finds areas in the superior temporal cortex responsive to phonological stimuli. However behavioural evidence to support the link between a phonological analysis deficit and auditory comprehension has not been yet shown. This study extends seminal work by Blumstein, Baker, and Goodglass (1977) to investigate the relationship between acoustic-phonological perception, measured through phonological discrimination, and auditory comprehension in a case series of Wernicke's aphasia participants. A novel adaptive phonological discrimination task was used to obtain reliable thresholds of the phonological perceptual distance required between nonwords before they could be discriminated. Wernicke's aphasia participants showed significantly elevated thresholds compared to age and hearing matched control participants. Acoustic-phonological thresholds correlated strongly with auditory comprehension abilities in Wernicke's aphasia. In contrast, nonverbal semantic skills showed no relationship with auditory comprehension. The results are evaluated in the context of recent neurobiological models of language and suggest that impaired acoustic-phonological perception underlies the comprehension impairment in Wernicke's aphasia and favour models of language which propose a leftward asymmetry in phonological analysis. {\textcopyright} 2011 Elsevier Ltd.",
keywords = "Auditory discrimination, Comprehension, Phonology, Semantics, Wernicke's Aphasia",
author = "Holly Robson and Keidel, {James L.} and {Lambon Ralph}, {Matthew A.} and Karen Sage",
year = "2012",
month = jan
doi = "10.1016/j.neuropsychologia.2011.11.022",
language = "English",
volume = "50",
pages = "276--288",
journal = "NEUROPSYCHOLOGIA",
issn = "0028-3932",
publisher = "Elsevier BV",
number = "2",

}

RIS

TY - JOUR

T1 - Revealing and quantifying the impaired phonological analysis underpinning impaired comprehension in Wernicke's aphasia

AU - Robson, Holly

AU - Keidel, James L.

AU - Lambon Ralph, Matthew A.

AU - Sage, Karen

PY - 2012/1

Y1 - 2012/1

N2 - Wernicke's aphasia is a condition which results in severely disrupted language comprehension following a lesion to the left temporo-parietal region. A phonological analysis deficit has traditionally been held to be at the root of the comprehension impairment in Wernicke's aphasia, a view consistent with current functional neuroimaging which finds areas in the superior temporal cortex responsive to phonological stimuli. However behavioural evidence to support the link between a phonological analysis deficit and auditory comprehension has not been yet shown. This study extends seminal work by Blumstein, Baker, and Goodglass (1977) to investigate the relationship between acoustic-phonological perception, measured through phonological discrimination, and auditory comprehension in a case series of Wernicke's aphasia participants. A novel adaptive phonological discrimination task was used to obtain reliable thresholds of the phonological perceptual distance required between nonwords before they could be discriminated. Wernicke's aphasia participants showed significantly elevated thresholds compared to age and hearing matched control participants. Acoustic-phonological thresholds correlated strongly with auditory comprehension abilities in Wernicke's aphasia. In contrast, nonverbal semantic skills showed no relationship with auditory comprehension. The results are evaluated in the context of recent neurobiological models of language and suggest that impaired acoustic-phonological perception underlies the comprehension impairment in Wernicke's aphasia and favour models of language which propose a leftward asymmetry in phonological analysis. © 2011 Elsevier Ltd.

AB - Wernicke's aphasia is a condition which results in severely disrupted language comprehension following a lesion to the left temporo-parietal region. A phonological analysis deficit has traditionally been held to be at the root of the comprehension impairment in Wernicke's aphasia, a view consistent with current functional neuroimaging which finds areas in the superior temporal cortex responsive to phonological stimuli. However behavioural evidence to support the link between a phonological analysis deficit and auditory comprehension has not been yet shown. This study extends seminal work by Blumstein, Baker, and Goodglass (1977) to investigate the relationship between acoustic-phonological perception, measured through phonological discrimination, and auditory comprehension in a case series of Wernicke's aphasia participants. A novel adaptive phonological discrimination task was used to obtain reliable thresholds of the phonological perceptual distance required between nonwords before they could be discriminated. Wernicke's aphasia participants showed significantly elevated thresholds compared to age and hearing matched control participants. Acoustic-phonological thresholds correlated strongly with auditory comprehension abilities in Wernicke's aphasia. In contrast, nonverbal semantic skills showed no relationship with auditory comprehension. The results are evaluated in the context of recent neurobiological models of language and suggest that impaired acoustic-phonological perception underlies the comprehension impairment in Wernicke's aphasia and favour models of language which propose a leftward asymmetry in phonological analysis. © 2011 Elsevier Ltd.

KW - Auditory discrimination

KW - Comprehension

KW - Phonology

KW - Semantics

KW - Wernicke's Aphasia

U2 - 10.1016/j.neuropsychologia.2011.11.022

DO - 10.1016/j.neuropsychologia.2011.11.022

M3 - Article

C2 - 22172546

VL - 50

SP - 276

EP - 288

JO - NEUROPSYCHOLOGIA

JF - NEUROPSYCHOLOGIA

SN - 0028-3932

IS - 2

ER -