Restoration of collagen and elastic fibre networks following treatment of photoaged skin with Serènesse, a novel over‐the‐counter anti‐ageing product

Research output: Contribution to journalLetterpeer-review

  • External authors:
  • L F Cotterell
  • P Halai
  • T W Griffiths


Chronic sun exposure induces profound changes to the dermal extracellular matrix (ECM) resulting in the loss of fibrillin-rich microfibrils (FRM) [1] and fibrillar collagen [2]. The gold standard topical treatment for photoaged skin is all-trans retinoic acid (tRA) [3]. The ‘Manchester Patch-Test’ (MPT) assay was first developed in 2001 as a short-term, exaggerated-use patch test protocol to test the potential efficacy of topical anti-ageing products [4].

Bibliographical metadata

Original languageEnglish
JournalJournal of the European Academy of Dermatology and Venereology
Early online date20 Aug 2021
Publication statusE-pub ahead of print - 20 Aug 2021