Response to “Determining Allele-Specific Protein Expression (ASPE) Using a Novel Quantitative Concatamer Based Proteomics Method”

Research output: Contribution to journalLetter


A recent publication in this journal reported the application of a targeted proteomic strategy using a quantitative concatemer (QconCAT) standard to the assessment of allele-specific expression of UGT2B15 claiming this methodology to be a “novel” approach (J. Proteome Res. 2018, 17 (10), 3606−3612, DOI:10.1021/acs.jproteome.8b00620). While the application is not common, the method was previously described and reported by our group in relation to the quantification of CYP2B6 alleles (J. Proteome Res. 2013, 12 (12), 5934−5942, DOI: 10.1021/pr400279u) to assess the expression of a prevalent polymorphism in a Caucasian population.

Bibliographical metadata

Original languageEnglish
Pages (from-to)574-574
JournalJ. Proteome Res.
Issue number1
Early online date16 Nov 2018
Publication statusPublished - 4 Jan 2019