Research in progress: Medical Research Council United Kingdom Refractory Asthma Stratification Programme (RASP-UK).

Research output: Contribution to journalArticle

  • External authors:
  • Liam G Heaney
  • Ratko Djukanovic
  • Ashley Woodcock
  • Samantha Walker
  • John G Matthews
  • Ian D Pavord
  • Peter Bradding
  • Chris E Brightling
  • Rekha Chaudhuri
  • Joseph R Arron
  • David F Choy
  • Douglas Cowan
  • Adel Mansur
  • Andrew Menzies-Gow
  • Ian Adcock
  • Kian F Chung
  • Chris Corrigan
  • Peter Coyle
  • Timothy Harrison
  • Sebastian Johnston
  • Peter Howarth
  • James Lordan
  • Ian Sabroe
  • Jeannette Bigler
  • Dirk Smith
  • Matthew Catley
  • Richard May
  • Lisa Pierre
  • Chris Stevenson
  • Glenn Crater
  • Frank Keane
  • Richard W Costello
  • Val Hudson
  • David Supple
  • Tim Hardman
  • Matthew Cattley

Abstract

The UK Refractory Asthma Stratification Programme (RASP-UK) will explore novel biomarker stratification strategies in severe asthma to improve clinical management and accelerate development of new therapies. Prior asthma mechanistic studies have not stratified on inflammatory phenotype and the understanding of pathophysiological mechanisms in asthma without Type 2 cytokine inflammation is limited. RASP-UK will objectively assess adherence to corticosteroids (CS) and examine a novel composite biomarker strategy to optimise CS dose; this will also address what proportion of patients with severe asthma have persistent symptoms without eosinophilic airways inflammation after progressive CS withdrawal. There will be interactive partnership with the pharmaceutical industry to facilitate access to stratified populations for novel therapeutic studies.

Bibliographical metadata

Original languageEnglish
JournalThorax
DOIs
Publication statusPublished - 23 Jul 2015

Related information

Researchers

View all